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Atopy is strongly and inversely related to family size, a pattern which is plausibly assumed to reflect a protective effect of early infection. The current study tested this hypothesis by case-referent analysis of an adult cohort in the UK. The study established that atopy, defined by prick tests to common aeroallergens, was less common among those from(More)
BACKGROUND It is suggested that the inverse relationship between allergic disease and family size reflects reduced exposure to early life infections, and that antibiotic treatment in childhood diminishes any protective effect of such infection. METHODS A birth cohort study was undertaken in 642 children recruited before birth and seen annually until the(More)
The present study aimed to determine if emotion regulation mediates the relationship between emotional maltreatment and disordered eating behavior in adolescents. Participants were 222 secondary school pupils (aged 14-18 years) from a state high school in the UK. Standardized questionnaire measures were used to gather self-report data on emotional abuse and(More)
A multicentre, prospective cohort study of childhood asthma was established in three European countries; the purpose of the project is the examination of factors which modify the relationship between allergen exposure in infant life and subsequent atopy and asthma. Dust samples were collected from the homes of 643 infants in a single town in the UK (the(More)
Objective: To examine smoking habits before and during pregnancy , as well as factors associated with smoking cessation, in three European settings. Methods: Women seeking antenatal care in Ashford (UK), Minorca and Barcelona (Spain) were recruited to the Asthma Multicenter Infant Cohort Study (AMICS). Questionnaires inquiring into the smoking habits of(More)
Local chest wall progression of chemotherapy/radiation-resistant breast cancer can result in substantial morbidity. In this retrospective review of 39 patients in this difficult clinical setting treated at Cancer Treatment Centers of America (Eastern Regional Medical Center), approximately one-half of the population experienced meaningful short-term(More)
0 The views, opinions, and findings contained-in this report are those of the authors and should not be construed as an official Department of Defense position, policy, or decision, unless so designated by other official documentation. 0 Acknowledgements. for their many contributions in the laboratory. We thank Denise Bussard and Pamela Mills for their work(More)
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