In view of numerous studies demonstrating that intracerebral implants of fetal neural tissue can promote functional recovery and structural repair in the damaged brain, the present study examined the potential use of neocortical transplantation in newborn rats that sustained hypoxic-ischemic brain injury. Ischemic insult was induced in Long-Evans,… (More)
Fetal neocortical transplants placed into frontal cortex aspiration lesion cavities in newborn rats have been shown to survive and exchange connections with the host brain. To further study the afferent innervation of such transplants, enzyme- and immunohistochemical techniques were employed to examine the distribution of cholinergic, catecholaminergic and… (More)
Vascular permeability was examined in fetal neocortical transplants grafted into the cerebral cortex of newborn rats. Methods based on the histochemical labeling of intravenously administered horseradish peroxidase or on the immunocytochemical demonstration of endogenous immunoglobulin showed the presence of a blood barrier within the transplants.
OBJECTIVE To review and evaluate available software tools for electronic health record-driven phenotype authoring in order to identify gaps and needs for future development. MATERIALS AND METHODS Candidate phenotype authoring tools were identified through (1) literature search in four publication databases (PubMed, Embase, Web of Science, and Scopus) and… (More)
Objective. Systematic review and analysis of definitions of translational research. Materials and methods. The final corpus was comprised of 33 papers, each read by at least 2 reviewers. Definitions were mapped to a common set of research processes for presentation and analysis. Influence of papers and definitions was further evaluated using citation… (More)
We all want our published work easily discoverable online, and often researchers choose journals based on their audience and coverage for that reason. Beyond your choice of journal, there are proactive steps to ensure your article is discoverable once it's been published. Regardless of how your article is made available online, it will need to be indexed by… (More)
Pineal glands from neonatal (0-1 day) Long-Evans black-hooded rats were transplanted into the cerebral hemispheres of litter mates for periods of 1 to 5.5 months. Grafts exhibited differentiated pinealocytes that were intensely immunoreactive for serotonin. Transplant vasculature was permeable to endogenous IgG, comprised fenestrated endothelia with wide… (More)
High dropout rates of addicts in treatment have long been attributed to a lack of motivation or readiness for rehabilitation. Two groups of subjects were compared on several demographic characteristics and several variables isolated as possible predictors of readiness for rehabilitation.
The findings presented tend to support already established trends reported in the literature concerning the performance of opiate users on standard psychological tests. Evidence which suggests that addicts are not functioning at full intellectual capacity was presented for the first time. Moreover, the use of psychological tests as outcome measures for drug… (More)