Pamela Horwitz

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The mechanism of activation of soluble guanylate cyclase purified from bovine lung by high molecular weight, nitrosyl-hemoprotein complexes is reported. Heme-containing, heme-deficient, and heme-reconstituted forms of guanylate cyclase were studied. Nitric oxide (NO) and nitroso compounds activated heme-containing and heme-reconstituted enzymes (over(More)
The effects of verapamil and diltiazem, calcium channel blockers, on aggregatory responses to ADP, arachidonic acid (AA), U46619, a thromboxane A2 mimic, and prostaglandin H2 (PGH2) were investigated in cat and rabbit platelet rich plasma. Results of the present study demonstrate that verapamil and diltiazem inhibit cat or rabbit platelet aggregation(More)
The purpose of the present study was to investigate in human platelet rich plasma the effects of amrinone, a cardiotonic agent, on platelet aggregation induced by ADP, arachidonic acid (AA), collagen, prostaglandin H2 (PGH2), and U46619, a substance reported to mimic the actions of thromboxane A2. Amrinone inhibited aggregatory responses to all substances(More)
12 October 2016 • Nursing Management Evidence has shown that unrestricted presence and participation of a patient support person can improve the safety of care, enhance patient and family experience and satisfaction, reduce costs, improve the management and continuity of care, and improve safety for older patients with impaired(More)
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