Pamela F. Jones

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Vascular endothelial growth factor (VEGF), which acts via members of a family of endothelial-specific receptor tyrosine kinases, is the only factor that has been shown definitively to play a role in the formation of the embryonic vasculature. Only one other family of receptor tyrosine kinases, comprising TIE1 and TIE2, is largely endothelial cell specific.(More)
TIE2 is a receptor-like tyrosine kinase expressed almost exclusively in endothelial cells and early hemopoietic cells and required for the normal development of vascular structures during embryogenesis. We report the identification of a secreted ligand for TIE2, termed Angiopoietin-1, using a novel expression cloning technique that involves intracellular(More)
Angiogenesis--the growth of new blood vessels from existing ones--is a prerequisite for the growth of solid tumours beyond a diameter of approximately 2 mm. In recent years, the angiopoietins have emerged as important regulators of angiogenesis. They mediate a delicate balance between vascular quiescence, regression and new growth, but their mechanism of(More)
OBJECTIVE To examine angiogenic growth factors in patients with early, untreated inflammatory arthritides and controls. METHODS Synovial membrane (SM) infiltrate and Ang1, Ang2, and vascular endothelial growth factor (VEGF) mRNA and protein expression were examined using immunohistochemistry and in situ hybridization. Synovial fluid (SF) VEGF,(More)
Since the discovery of the angiopoietins, much interest has been focused on their biological actions and their potential use as therapeutic targets. It is generally accepted that the angiopoietins play an important role in angiogenesis and hence are described as angiogenic factors. However, it is becoming increasingly clear that this is not their only role(More)
Mouse models are becoming increasingly important in the study of molecular mechanisms of colorectal disease and in the development of novel therapeutics. To enhance this phase of preclinical research, cost-effective, easy to use noninvasive imaging is required to detect and monitor changes in the colon wall associated with disease pathology. This study(More)
The angiopoietins represent a recently discovered family of angiogenic factors that recognise and specifically bind to the endothelial cell-specific Tie2 receptor tyrosine kinase. The specific biological functions of the angiopoietins have not yet been elucidated, although transgenic technology has shown the critical roles that these proteins have in(More)
Biological mathematics is based on the development of mathematical descriptions of biological systems and behaviour. We are interested in developing mathematical models of capillary sprouting, and have adopted a novel approach to our modelling, in that the mathematics is based on the biochemistry underpinning cell behaviour. By considering the crucial steps(More)
We report the identification of ligands for Tyro 3 (alternatively called Sky, rse, brt, or tif) and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases. These ligands correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related to protein S but lacking any(More)
Angiogenesis--the growth of new blood vessels from existing ones--is a prerequisite for the growth of solid tumours beyond a diameter of approximately 2 mm. In recent years, the angiopoietins have emerged as important regulators of angiogenesis. They mediate a delicate balance between vascular quiescence, regression and new growth, but their mechanism of(More)