Pallavi Bassi

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INTRODUCTION Vagina, due to its anatomical position and physiological characteristics is increasingly being explored as a site for drug delivery in recent years. This route coupled with bioadhesion phenomena has born fruitful results in delivering drugs both locally as well as systemically. AREAS COVERED Bioadhesive vaginal drug delivery system has been(More)
IMPORTANCE OF THE FIELD In formulation development, weakly acidic or basic drugs pose a major challenge as the solubility depends significantly on pH of the dissolution media. This gives rise to pH-dependent drug release, as the formulation is exposed to different pH ranges in the gastrointestinal tract. This indicates a need to carry out formulation(More)
Increasing incidence of resistance to azole antifungals has highlighted the importance of the use of alternative therapeutic agents such as nystatin for the treatment of vulvovaginal candidiasis. The aim of the present study was to develop and characterize locally acting, film formulation for the treatment of candidiasis using a derivatized natural polymer.(More)
In this study a rapid, simple and sensitive assay to quantify clozapine in human plasma by using reverse phase high performance liquid chromatographic method has been developed. Clozapine was extracted from human plasma using a mixture of chloroform: n-hexane 50:50 employing liquid-liquid extraction method. The calibration curve was found to be linear in(More)
Bioadhesive films using tamarind seed polysaccharide were prepared for the treatment of candida vaginitis using nystatin as the model drug. Films were prepared by solvent casting method. A 32 factorial design was employed to study the effect of independent variables (polymer and plasticizer concentration) on a range of dependent variables namely mechanical,(More)
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