Pakeeza Arzoo Shaiq

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BACKGROUND Genetic predisposition to psoriasis, an inflammatory skin disease affecting 0·2-4% of the world population, is well established. Thus far, 41 psoriasis susceptibility loci reach genome-wide significance (P ≤ 5 × 10(-8) ). Identification of genetic susceptibility loci in diverse populations will help understand the underlying biology of psoriasis(More)
Exome sequencing has become more and more affordable and the technique has emerged as an important diagnostic tool for monogenic disorders at early stages of investigations, in particular when clinical information is limited or unspecific as well as in cases of genetic heterogeneity. We identified a consanguineous Pakistani family segregating an autosomal(More)
Over forty-one genetic susceptibility loci of genome-wide significance (P < 5 × 10 −8) are known for psoriasis, a common complex genetic disease characterized by epidermal hyperproliferation and cutaneous inflammation. The most strongly associated of these loci maps to the HLA-C gene in the major histocompatibility complex (MHC) on chromosome 6p21.3 (Tsoi(More)
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