Padma Narayan Bhandare

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OBJECTIVES The present study was undertaken to provide the health professionals who were working at a tertiary care hospital, with a simple method to report Adverse Drug Reactions (ADRs) and to monitor, document and to evaluate them according to the set criteria. METHOD AND MATERIALS This study was conducted over a period of 15 months from 1st Jan' 2008(More)
The imidazole alpha 2-adrenoceptor agonist, clonidine, exerts a dual action on ethanol-induced gastric lesions. At lower doses, it has a gastroprotective effect which is also seen with two other alpha 2-adrenoceptor agonists - the catecholamine, alpha-methyldopa and the guanidine, guanabenz. The gastroprotective action of the three drugs is prevented by the(More)
The non-selective beta-adrenoceptor antagonist, propranolol, has a protective effect on ethanol-induced gastric haemorrhagic lesions in mice when given in doses of 2.5, 5.0 and 10 mg/kg either parenterally (i.p.) or orally. The effect was more marked after oral administration. Another non-selective beta-adrenoceptor antagonist, timolol, failed to protect(More)
Endogenous nitric oxide has been proposed as one of the mediators of gastric cytoprotection. We studied the effect of the vasodilator hydralazine which acts via nitric oxide and thus is expected to have a gastroprotective action. However, hydralazine aggravates ethanol-induced gastric lesions. This effect is not influenced by pretreatment with the selective(More)
INTRODUCTION Geriatric population is on the rise throughout the world, hence the quality and the safety of prescribing in the elderly is a global healthcare concern. It is important for the healthcare providers to be aware of the limitations in prescribing certain drugs to the elderly. This study was an attempt to shed light on the utilization pattern of(More)
Diabetes mellitus (DM) is a common disease which usually manifests in the form of polyuria, polydipsia, weight loss, fatigue, weakness, blurry vision, frequent skin infections, and slow healing of skin lesions. Taste disturbances like ageusia, hypogeusia and dysgeusia have been associated with DM. The early diagnosis of DM based on these symptoms is very(More)
Large doses of the imidazoline alpha 2 adrenoreceptor agonist clonidine aggravate ethanol-induced gastric lesions. The alpha 2 adrenoceptor antagonist phentolamine, the opioid antagonist naloxone and the H2 antagonist cimetidine do not prevent this action of clonidine suggesting that it is not mediated by alpha 2, opioid or H2 receptors. Further, like(More)
There are coflicting reports regarding the role of GABA in morphine analgesia. While-sorne investigators have reported that treatment with GABAA receptor agonist muscimol and GABA transaminase inhibitors potentiates morphine analgesia (2.4.6) others have reported antagonism of morphine analgesia (8.10). In view of these conflicting reports and since the(More)
The non-selective beta-adrenoceptor antagonist, propranolol, has been reported to protect against gastric injury in mice, an effect only partly due to prostaglandin release. This study was designed to confirm the gastric cytoprotective effect of propranolol in another species of animal, the rat, and investigate further its mechanism of action. Our results(More)
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