Pablo Smircich

Publications8
h-index4
Citations61
Highly Influential Citations6
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Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni
Genome sequences are available for the human blood flukes, Schistosoma japonicum, S. mansoni and S. haematobium. Functional genomic approaches could aid in identifying the role and importance of… Expand
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Conservation and diversification of small RNA pathways within flatworms
BackgroundSmall non-coding RNAs, including miRNAs, and gene silencing mediated by RNA interference have been described in free-living and parasitic lineages of flatworms, but only few key factors of… Expand
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Draft Genome Sequence of the UV-Resistant Antarctic Bacterium Sphingomonas sp. Strain UV9
We report the draft genome sequence of the Antarctic UV-resistant bacterium Sphingomonas sp. strain UV9. The strain has a genome size of 4.25 Mb, a 65.62% GC content, and 3,879 protein-coding… Expand
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UTRme: A Scoring-Based Tool to Annotate Untranslated Regions in Trypanosomatid Genomes
Most signals involved in post-transcriptional regulatory networks are located in the untranslated regions (UTRs) of the mRNAs. Therefore, to deepen our understanding of gene expression regulation,… Expand
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Nuclear Compartmentalization Contributes to Stage-Specific Gene Expression Control in Trypanosoma cruzi
In the protozoan parasite Trypanosoma cruzi, as in other trypanosomatids, transcription of protein coding genes occurs in a constitutive fashion, producing large polycistronic transcription units.… Expand
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High Throughput Approaches to Unravel the Mechanism of Action of a New Vanadium-Based Compound against Trypanosoma cruzi
Treatment for Chagas disease, a parasitosis caused by Trypanosoma cruzi, has always been based on two drugs, nifurtimox and benznidazole, despite the toxic side effects described after prolonged… Expand
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Upstream ORFs Influence Translation Efficiency in the Parasite Trypanosoma cruzi
It is generally accepted that the presence of ORFs in the 5′ untranslated region of eukaryotic transcripts modulates the production of proteins by controlling the translation initiation rate of the… Expand
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Compositional Analysis of Flatworm Genomes Shows Strong Codon Usage Biases Across All Classes
In the present work, we performed a comparative genome-wide analysis of 22 species representative of the main clades and lifestyles of the phylum Platyhelminthes. We selected a set of 700 orthologous… Expand