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Circadian clocks are biological oscillators that regulate molecular, physiological, and behavioral rhythms in a wide variety of organisms. While behavioral rhythms are typically monitored over many cycles, a similar approach to molecular rhythms was not possible until recently; the advent of real-time analysis using transgenic reporters now permits the(More)
Circadian clocks are influenced by social interactions in a variety of species, but little is known about the sensory mechanisms underlying these effects. We investigated whether social cues could reset circadian rhythms in Drosophila melanogaster by addressing two questions: Is there a social influence on circadian timing? If so, then how is that influence(More)
Cryptochromes are flavin/pterin-containing proteins that are involved in circadian clock function in Drosophila and mice. In mice, the cryptochromes Cry1 and Cry2 are integral components of the circadian oscillator within the brain and contribute to circadian photoreception in the retina. In Drosophila, cryptochrome (CRY) acts as a photoreceptor that(More)
Previously, we reported effects of the cry b mutation on circadian rhythms in period and timeless gene expression within isolated peripheral Drosophila tissues. We relied on luciferase activity driven by the respective regulatory genomic elements to provide real-time reporting of cycling gene expression. Subsequently, we developed a tool kit for the(More)
Creating artificial life forms through evolutionary robotics faces a "chicken and egg" problem: Learning to control a complex body is dominated by problems specific to its sensors and effectors, while building a body that is controllable assumes the pre-existence of a brain. The idea of coevolution of bodies and brains is becoming popular, but little work(More)
Creating artificial life forms through evolutionary robotics faces a “chicken and egg” problem: learning to control a complex body is dominated by inductive biases specific to its sensors and effectors, while building a body which is controllable is conditioned on the pre-existence of a brain. The idea of co-evolution of bodies and brains is becoming(More)
Evolutionary and coevolutionary techniques have become a popular area of research for those interested in automated design. One of the cutting edge issues in this eld is the ability to apply these techniques to real physical systems with all the complexities and a ordances that such systems present. Here we present a selection of our work each of which(More)
The difficulties associated with designing, building, and controlling robots have led their development to a stasis: Applications are limited mostly to repetitive tasks with predefined behavior. Over the last few years we have been trying to address this challenge through an alternative approach: Rather than trying to control an existing machine or create a(More)
Evolution of Complexity in Real-World Domains A dissertation presented to the Faculty of the Graduate School of Arts and Sciences of Brandeis University, Waltham, Massachusetts by Pablo Funes Artificial Life research brings together methods from Artificial Intelligence (AI), philosophy and biology, studying the problem of evolution of complexity from what(More)
This chapter describes our work in evolution of buildable designs using miniature plastic bricks as modular components. Lego1 bricks are well known for their flexibility when it comes to creating low cost, handy designs of vehicles and structures. Their simple modular concept make toy bricks a good ground for doing evolution of computer simulated structures(More)