Pablo Astudillo

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Cell and tissue stiffness have been known to contribute to both developmental and pathological signalling for some time, but the underlying mechanisms remain elusive. Integrins and their associated adhesion signalling complexes (IACs), which form a nexus between the cell cytoskeleton and the extracellular matrix, act as a key force sensing and transducing(More)
Three decades after the beginning of the study of the Wnt signaling pathway, major contributions have been made to elucidate the molecular mechanisms that regulate this signaling pathway and its role in development, homeostasis and disease. However, there is still a lack of understanding about the relationships between Wnt signaling and cell-extracellular(More)
This paper presents practical aspects related with the operation, compensation, and protection of high-power cycloconverters used in the mining industry. Practical recommendations related with startup, compensation requirements, operational characteristics, and unexpected shutdown process are described. Fuseless characteristics of modern cycloconverters are(More)
O comportamento eletroquímico em função da estrutura de uma série de derivados dos ácidos cafeico e ferúlico, assim como de seus precursores catecol e guaiacol, eletroquimicamente ativos, foi avaliado por voltametria cíclica. Os resultados revelaram que as condições experimentais são a chave para as mudanças no mecanismo de oxidação do guaiacol e ácido(More)
Cations derived from 1,2-bis(benzimidazolium)ethane can penetrate the cavity of dibenzo-24-crown-8 macrocycles to produce a new family of [2]pseudorotaxanes. These supramolecular structures are held together by a series of charge-assisted hydrogen bonds (+)N-H[dot dot dot]O, ion-dipole and pi-stacking interactions. These new adducts were fully characterised(More)
In mixtures of trichloroacetate ion and trichloroacetic acid in acetonitrile, trichloromethyl radicals are produced as a result of the redox reaction between the acid and its conjugate base. The reaction follows a loop mechanism in which the trichloroacetic acid is slowly consumed by proton reduction while the trichloroacetate ion is oxidized like in an(More)
This paper presents the study of dynamic interactions between passive filters and high power cycloconverters drives. The dynamic interaction considers the impact of connection and disconnection of passive filters operating in conjunction with high power cycloconverters. The inrush currents generated by filter connection affects the cycloconverter operation.(More)
PURPOSE Multipotent mesenchymal stem cells (MSCs) have the capability to differentiate down adipocyte, osteocyte and chondrocyte lineages and as such offer a range of potential therapeutic applications. The composition and stiffness of the extracellular matrix (ECM) environment that surrounds cells dictates their transcriptional programme, thereby affecting(More)
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