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The increase in complexity of computational neuron models makes the hand tuning of model parameters more difficult than ever. Fortunately, the parallel increase in computer power allows scientists to automate this tuning. Optimization algorithms need two essential components. The first one is a function that measures the difference between the output of the(More)
The increase in available computational power and the higher quality of experimental recordings have turned the tuning of neuron model parameters into a problem that can be solved by automatic global optimization algorithms. Neurofitter is a software tool that interfaces existing neural simulation software and sophisticated optimization algorithms with a(More)
The electrical activity of a neuron is strongly dependent on the ionic channels present in its membrane. Modifying the maximal conductances from these channels can have a dramatic impact on neuron behavior. But the effect of such modifications can also be cancelled out by compensatory mechanisms among different channels. We used an evolution strategy with a(More)
Realistic bottom-up modelling has been seminal to understanding which properties of microcircuits control their dynamic behaviour, such as the locomotor rhythms generated by central pattern generators. In this article of the TINS Microcircuits Special Feature, we review recent modelling work on the leech-heartbeat and lamprey-swimming pattern generators as(More)
We recently reproduced the complex electrical activity of a Purkinje cell (PC) with very different combinations of ionic channel maximum conductances, suggesting that a large parameter space is available to homeostatic mechanisms. It has been hypothesized that cytoplasmic calcium concentrations control the homeostatic activity sensors. This raises many(More)
Realistic bottom-up modelling has been seminal to understanding which properties of microcircuits control their dynamic behaviour, such as the locomotor rhythms generated by central pattern generators. In this article of the TINS Microcircuits Special Feature, we review recent modelling work on the leech-heartbeat and lamprey-swimming pattern generators as(More)
The absolute muon flux between 20 and 3000 GeV is measured with the L3 magnetic muon spectrometer for zenith angles ranging from 0 • to 58 •. Due to the large exposure of about 150 m 2 sr d, and the excellent momentum resolution of the L3 muon chambers, a precision of 2.3% at 150 GeV in the vertical direction is achieved. The ratio of positive to negative(More)
Activity homeostasis designates bio-mechanisms that regulate the activity of a neuron through the dynamic expression of ion channels or synapses [1]. We have recently shown [2] that it is possible to reproduce the complex activity of a Purkinje cell (PC) with very different combinations of ionic channel maximum conductances. However , if the global effect(More)