PM Roekaerts

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T HE DOSE-RESPONSE curve for narcotic or opioid anesthesia is not linear but reaches a plateau beyond a certain plasma concentration.'J In patients undergoing cardiac surgery, increasing the plasma concentration of fentanyl above 20 ng/mL had little effect on the incidence of hypertension following sternotomy or aortic dissection.2,3 Similarly, high-dose(More)
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