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The brain undergoes many structural and functional changes during aging. Some of these changes are regulated by estrogens which act mainly through their intracellular receptors, estrogen receptor ERalpha and ERbeta. The expression of these receptors is regulated by several factors including their own ligand estrogen, and others such as growth hormone and(More)
Estrogen receptor (ER), which mediates the multiple effects of estrogen in brain, is regulated by several factors including its own ligand. In the present study, we have examined the effect of age, sex and gonadal steroids (estrogen and testosterone) on the level of ERalpha and ERbeta in the cerebral cortex of AKR mice. Adult and old mice of both sexes were(More)
Estrogen actions are mainly mediated by estrogen receptor (ER)alpha and ERbeta which in turn are regulated by several factors including age, sex and gonadal steroid hormones 17beta-estradiol and testosterone. In the present study, we have used nuclear run-off assay to examine the effect of these factors on the rate of transcription of ERalpha and ERbeta of(More)
BACKGROUND Type 2 diabetes mellitus is a multisystem disorder that is associated with number of complications. Patient's awareness and practices are crucial components in reducing the burden of diseases and its complications. AIM To assess patient's knowledge about their disease and its complications, practices, treatment seeking behavior and average(More)
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