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The objective of this study was to improve the oral bioavailability and therapeutic efficacy of albendazole (ABZ) employing solid dispersion and cyclodextrin complexation techniques. Solid dispersion (dispersion) was prepared using ABZ and polyvinylpyrrolidone (PVP) polymer (1:1 weight ratio). Ternary inclusion complex (ternary complex) was prepared using(More)
Large porous microparticles of PLGA entrapping insulin were prepared by solvent evaporation method and evaluated in diabetes induced rat for its efficacy in maintaining blood sugar level from a single oral dose. Incorporation of Eudragit L30D (0.03% w/v) in the external aqueous phase resulted in formation of pH responsive enteric coated polymer particles(More)
BACKGROUND India, the largest democracy in the world, is with a federal structure of 29 states and 7 union territories. With a population of more than 1.2 billion, resource is always a constraint and so is in the health system too. In the federal structure, providing healthcare is largely the responsibility of state governments. Medicines are important(More)
Glipizide microparticles made with Eudragit (RS 100 and RL 100), prepared by emulsion solvent evaporation technique were evaluated for various in-vitro properties viz. encapsulation efficiency, particle size and surface morphology, drug release pattern and in-vivo hypoglycaemic activity. The optimized formulation parameters were used to prepare smooth and(More)
The main aim of the study was to investigate the mechanisms of the stabilizing effect of poly(vinylpyrrolidone) (PVP) on amorphous albendazole (ABZ). Solid dispersions of ABZ with PVP polymers and with a copolymer containing poly(vinylacetate) (PVP/VA) were prepared using the solvent casting method. The effects of PVP molecular weight, composition and(More)
Diabetes mellitus (DM) is a complex metabolic disorder and which is one of the major health crisis the world facing today. There is no permanent cure for DM, however. It could be managed successfully with existing oral hypoglycaemic agents and insulin. Most of the time diabetic management will be unsuccessful in outpatients because of lack of health(More)
Occurrences of gastroenteritis have been increasing and become a threat to public health. While the morbidity of rotavirus gastroenteritis are extensive in developing countries like India; the date on the cost of illness are not easily available. The present study was aimed to analyze and compare the expenditure incurred during community and hospital(More)
Diabetes mellitus (DM) is a complex metabolic disorder and which is one of the major health crisis the world facing today. There is no permanent cure for DM, however. It could be managed successfully with existing oral hypoglycaemic agents and insulin. Most of the time diabetic management will be unsuccessful in outpatients because of lack of health(More)
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