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Identification of a novel gene involved in pilin glycosylation in Neisseria meningitidis
TLDR
Insertional mutations were constructed in pglA in a range of meningococcal strains with well‐defined lipopolysaccharide (LPS) or pilin‐linked glycan structures to determine whether p glA had a role in the biosynthesis of these molecules, suggesting that PglA is a glycosyltransferase involved in the addition of galactose of the trisaccharide substituent of pilin. Expand
A lipopolysaccharide-deficient mutant of Neisseria meningitidis elicits attenuated cytokine release by human macrophages and signals via toll-like receptor (TLR) 2 but not via TLR4/MD2.
TLDR
Evidence is provided that N. meningitidis contains components other than LPS that can elicit biological responses via pathways that are independent of the TLR4/MD2 receptor system, and TLR2 is one of these alternate pathways. Expand
Topology of outer membrane porins in pathogenic Neisseria spp
TLDR
The results suggest that the longest loops in Escherichia coli are immunodominant, provide the binding sites for bactericidal antibodies, and display the greatest variation among different strains. Expand
Modification of Lipid A Biosynthesis inNeisseria meningitidis lpxL Mutants: Influence on Lipopolysaccharide Structure, Toxicity, and Adjuvant Activity
TLDR
Modification of meningococcal lipid A biosynthesis can lead to novel LPS species more suitable for inclusion in human vaccines, as the combination of reduced toxicity and retained adjuvant activity has not been reported before for either lpxL or lpxM mutants from other bacterial species. Expand
A Neisserial autotransporter NalP modulating the processing of other autotransporters
TLDR
It is proposed that, apart from the autoproteolytic processing, NalP can process App and IgA protease and hypothesize that this function of NAlP could contribute to the virulence of the organism. Expand
The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis.
TLDR
A locus of three LPS biosynthetic genes involved in the biosynthesis of one of these terminal structures, lacto-N-neotetraose, was examined, and the potential for strains to express alternative immunotypes was established. Expand
Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC‐SIGN and modulates dendritic cell function
TLDR
The use of lgtB LPS may provide a powerful instrument to selectively induce the desired arm of the immune response and potentially increase vaccine efficacy. Expand
The Omp85 protein of Neisseria meningitidis is required for lipid export to the outer membrane
TLDR
It is demonstrated, by fractionation of inner and outer membranes, that lipopolysaccharide and phospholipids mostly disappeared from the outer membrane and instead accumulated in the inner membrane, upon depletion of Omp85. Expand
Outer membrane composition of a lipopolysaccharide‐deficient Neisseria meningitidis mutant
TLDR
The presence of the capsular polysaccharide turned out to be essential for viability without LPS, as demonstrated by using a strain in which LPS biosynthesis could be switched on or off through a tac promoter‐controlled lpxA gene. Expand
Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa.
TLDR
Although PagL is most likely active as a monomer, its active site architecture shows high resemblance to that of the dimeric 12-stranded outer membrane phospholipase A. Expand
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