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A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
Surface‐exposed calreticulin (ecto‐CRT) and secreted ATP are crucial damage‐associated molecular patterns (DAMPs) for immunogenic apoptosis. Inducers of immunogenic apoptosis rely on an endoplasmicExpand
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Liposomes for photodynamic therapy.
Photodynamic therapy (PDT) is an evolving modality for the treatment of superficial tumors. The technique utilizes photosensitizing agents that are able to photochemically eradicate malignant cells.Expand
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The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin*
In this study, we elucidate signaling pathways induced by photodynamic therapy (PDT) with hypericin. We show that PDT rapidly activates JNK1 while irreversibly inhibiting ERK2 in several cancer cellExpand
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Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, includingExpand
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Cytotoxicity of some medicinal plant extracts used in Tanzanian traditional medicine.
Using the ethnomedical data approach, some Tanzanian plants that are used in Tanzanian traditional medicine for cancer or non-cancer diseases were collected and evaluated for cytotoxic activity. TheExpand
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Structure-Based Identification of OATP1B1/3 Inhibitors
Several recent studies show that inhibition of the hepatic transport proteins organic anion-transporting polypeptide 1B1 (OATP1B1) and 1B3 (OATP1B3) can result in clinically relevant drug-drugExpand
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Targeting of the photocytotoxic compound AlPcS4 to hela cells by transferrin conjugated peg‐liposomes
Photodynamic therapy has attracted increasing interest over the last few years, whereby the activation of photosensitizers by light causes the production of reactive oxygen species (ROS), such asExpand
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The antiplasmodial activity of isolates from Ajuga remota.
Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. Its two known isolates ajugarin-1 (1) and ergosterol-5,8-endoperoxide (3) and a new isolate 8-O-acetylharpagideExpand
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Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish
Dravet syndrome (DS) is a genetic encephalopathy that is characterized by severe seizures and prominent co-morbidities (e.g., physical, intellectual disabilities). More than 85% of the DS patientsExpand
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Hypericin in cancer treatment: more light on the way.
Photodynamic therapy (PDT) has been described as a promising new modality for the treatment of cancer. PDT involves the combination of a photosensitizing agent (photosensitizer), which isExpand
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