Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum.
A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression.
- Jaskaran Singh, M. Fedgchin, L. van Nueten
- Psychology, MedicineAmerican Journal of Psychiatry
- 8 April 2016
OBJECTIVE Ketamine, an N-methyl-d-aspartate glutamate receptor antagonist, has demonstrated a rapid-onset antidepressant effect in patients with treatment-resistant depression. This study evaluated…
Antipsychotic drugs induce similar effects on the release of dopamine and noradrenaline in the medial prefrontal cortex of the rat brain.
Suppression of the clinical and cytokine response to endotoxin by RWJ‐67657, a p38 mitogen‐activated protein‐kinase inhibitor, in healthy human volunteers
Inhibitors of the p38 mitogen‐activated protein kinase (p38MAPK) have been used to study the signalling pathway of the immune response and demonstrated that blocking p38 MAPK could mitigate the pro‐inflammatory response and improve survival after endotoxaemia.
Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder
- P. Bonaventure, C. Dugovic, T. Lovenberg
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 August 2012
JNJ-18038683 enhanced serotonin transmission, antidepressant-like behavior, and REM sleep suppression induced by citalopram in rodents and in healthy human volunteers, demonstrating that the effect of 5-HT7 blockade on REM sleep translated from rodents to humans.
Treatment-resistant depression and peripheral C-reactive protein
It is suggested that MDD patients stratified for pro-inflammatory biomarkers, like CRP, have a distinctive clinical profile that might be responsive to second-line treatment with anti-inflammatory drugs.
Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor
- J. Westra, B. Doornbos-van der Meer, P. de Boer, M. V. van Leeuwen, M. V. van Rijswijk, P. Limburg
- Biology, MedicineArthritis research & therapy
- 21 June 2004
It was shown that monocyte-derived macrophages have a high constitutive production of matrix metalloproteinase 9, which is not affected by p38 MAPK inhibition, and the results presented here may have important implications for the treatment of rheumatoid arthritis.
Peripheral Blood Cell–Stratified Subgroups of Inflamed Depression
Pharmacological fMRI: Effects of subanesthetic ketamine on resting-state functional connectivity in the default mode network, salience network, dorsal attention network and executive control network☆