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Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis
The Spx protein of Bacillus subtilis represses activator-stimulated transcription by interacting with the C-terminal domain of RNA polymerase (RNAP) α subunit. Its concentration increases in cellsExpand
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A regulatory protein that interferes with activator-stimulated transcription in bacteria
Transcriptional activator proteins in bacteria often operate by interaction with the C-terminal domain of the α-subunit of RNA polymerase (RNAP). Here we report the discovery of an “anti-α” factorExpand
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Spatial variability overwhelms seasonal patterns in bacterioplankton communities across a river to ocean gradient
Few studies of microbial biogeography address variability across both multiple habitats and multiple seasons. Here we examine the spatial and temporal variability of bacterioplankton communityExpand
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Redox‐sensitive transcriptional control by a thiol/disulphide switch in the global regulator, Spx
The Spx protein is indispensable for survival of Bacillus subtilis under disulphide stress. Its interaction with the α‐subunit of RNA polymerase is required for transcriptional induction of genesExpand
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Spx-RNA polymerase interaction and global transcriptional control during oxidative stress.
  • P. Zuber
  • Biology, Medicine
  • Journal of bacteriology
  • 1 April 2004
Spx is a unique RNA polymerase (RNAP)-binding protein that is highly conserved among low-G+C-content gram-positive bacteria and certain members of the Mollicutes . In the spore-forming bacteriumExpand
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Anaerobic growth of a "strict aerobe" (Bacillus subtilis).
There was a long-held belief that the gram-positive soil bacterium Bacillus subtilis is a strict aerobe. But recent studies have shown that B. subtilis will grow anaerobically, either by usingExpand
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Management of oxidative stress in Bacillus.
  • P. Zuber
  • Biology, Medicine
  • Annual review of microbiology
  • 8 September 2009
The spore-forming bacterium and model prokaryotic genetic system, Bacillus subtilis, is extremely useful in the study of oxidative stress management through proteomic and genome-wide transcriptomicExpand
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Characterization of anaerobic fermentative growth of Bacillus subtilis: identification of fermentation end products and genes required for growth.
Bacillus subtilis can grow anaerobically by respiration with nitrate as a terminal electron acceptor. In the absence of external electron acceptors, it grows by fermentation. Identification ofExpand
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Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase.
Spx, a global transcription regulator in Bacillus subtilis, interacts with the C-terminal domain of the alpha subunit (alphaCTD) of RNA polymerase to control gene expression under conditions ofExpand
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Identification of a genetic locus required for biosynthesis of the lipopeptide antibiotic surfactin in Bacillus subtilis.
Surfactin is a lipopeptide antibiotic produced by the cells of Bacillus subtilis ATCC 21332. A genetic locus responsible for surfactin production (sfp) was transferred from ATCC 21332 to JH642, aExpand
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