• Publications
  • Influence
CCR5 promoter polymorphism and HIV-1 disease progression
BACKGROUND The rate of progression to AIDS varies among individuals infected with HIV-1. Factors responsible include two inherited human alleles, CCR5 delta32 and CCR2-641, which alter theExpand
  • 402
  • 24
Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people
Malaria therapy, experimental, and epidemiological studies have shown that erythrocyte Duffy blood group-negative people, largely of African ancestry, are resistant to erythrocyte Plasmodium vivaxExpand
  • 294
  • 24
Plasmodium malariae and Plasmodium ovale--the "bashful" malaria parasites.
Although Plasmodium malariae was first described as an infectious disease of humans by Golgi in 1886 and Plasmodium ovale identified by Stevens in 1922, there are still large gaps in our knowledge ofExpand
  • 225
  • 22
Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America
The mechanistic basis for chloroquine resistance (CQR) in Plasmodium falciparum recently has been linked to the polymorphic gene pfcrt. Alleles associated with CQR in natural parasite isolates harborExpand
  • 173
  • 21
Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified
BackgroundCC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus-1 (HIV-1). Recently, an inactive CCR5 allele (designated here asExpand
  • 444
  • 20
Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations
Geographic overlap between malaria and the occurrence of mutant hemoglobin and erythrocyte surface proteins has indicated that polymorphisms in human genes have been selected by severe malaria.Expand
  • 315
  • 17
Plasmodium vivax Transmission in Africa
Malaria in sub-Saharan Africa has historically been almost exclusively attributed to Plasmodium falciparum (Pf). Current diagnostic and surveillance systems in much of sub-Saharan Africa are notExpand
  • 66
  • 15
Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea.
In Papua New Guinea (PNG), numerous blood group polymorphisms and hemoglobinopathies characterize the human population. Human genetic polymorphisms of this nature are common in malarious regions, andExpand
  • 197
  • 13
Comparing the Ex Vivo Fitness of CCR5-Tropic Human Immunodeficiency Virus Type 1 Isolates of Subtypes B and C
ABSTRACT Continual human immunodeficiency virus type 1 (HIV-1) evolution and expansion within the human population have led to unequal distribution of HIV-1 group M subtypes. In particular, recentExpand
  • 201
  • 11
Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea
ObjectiveCytochrome P450 2B6 (CYP2B6) is involved in the metabolism of artemisinin drugs, a novel series of antimalarials. Our aim was to analyze the prevalence of the most commonly observed CYP2B6Expand
  • 96
  • 11