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- Publications
- Influence
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
- E. Binder, D. Salyakina, +36 authors B. Muller-Myhsok
- Biology, Medicine
- Nature Genetics
- 1 December 2004
The stress hormone–regulating hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the causality as well as the treatment of depression. To investigate a possible association between… Expand
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci
- J. Gelernter, H. Kranzler, +11 authors L. Farrer
- Biology, Medicine
- Molecular Psychiatry
- 2014
We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-American (AA) populations, with replication in independent samples of EAs, AAs and Germans. Our sample for discovery… Expand
SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression
- P. Zill, T. Baghai, +6 authors M. Ackenheil
- Biology, Medicine
- Molecular Psychiatry
- 1 November 2004
Tryptophan hydroxylase (TPH), being the rate-limiting enzyme in the biosynthesis of serotonin plays a major role as candidate gene in several psychiatric disorders. Recently, a second TPH isoform… Expand
Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.
- T. Frodl, C. Schüle, +9 authors E. Meisenzahl
- Psychology, Medicine
- Archives of general psychiatry
- 1 April 2007
CONTEXT
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression.
OBJECTIVE
To examine the effect of the BDNF… Expand
Genetics of suicide
- B. Bondy, A. Buettner, P. Zill
- Psychology, Medicine
- Molecular Psychiatry
- 1 April 2006
The concept that genetic factors contribute to the complex trait of suicidal behaviour has stimulated much work aimed at identifying susceptibility genes. So far molecular genetic studies focused on… Expand
GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence.
- M. Soyka, U. W. Preuss, V. Hesselbrock, P. Zill, G. Koller, B. Bondy
- Biology, Medicine
- Journal of psychiatric research
- 1 February 2008
Gamma-aminobutyric acid (GABA) A receptors are believed to mediate some of the physiological and behavioral actions of ethanol. Recent studies have suggested that genetic variants of the GABA-A… Expand
Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
- T. Frodl, N. Koutsouleris, +12 authors E. Meisenzahl
- Psychology, Medicine
- Molecular Psychiatry
- 1 July 2008
The serotonergic system is involved in the pathophysiology of major depression as well as in the early central nervous system development and adult neuroplasticity. The aim of the study was to… Expand
Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
Angiotensin-converting enzyme (ACE) is assumed to influence the activity of the hypothalamic-pituitary-adrenocortical (HPA) system, which shows hyperactivity in the majority of patients with major… Expand
Genome-wide association study of alcohol dependence.
- J. Treutlein, S. Cichon, +26 authors M. Rietschel
- Biology, Medicine
- Archives of general psychiatry
- 1 July 2009
CONTEXT
Alcohol dependence is a serious and common public health problem. It is well established that genetic factors play a major role in the development of this disorder. Identification of genes… Expand
Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression.
- T. Frodl, E. Meisenzahl, +11 authors H. Möller
- Psychology, Medicine
- Archives of general psychiatry
- 1 February 2004
BACKGROUND
Substantial evidence supports a role for dysfunction of the serotonin transporter in the pathogenesis of major depression. Several studies have found reciprocal interactions between the… Expand