Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
- Jéssica Mariani, G. Coppola, +13 authors F. Vaccarino
- Biology, Medicine
- Cell
- 16 July 2015
Autism spectrum disorder (ASD) is a disorder of brain development. Most cases lack a clear etiology or genetic basis, and the difficulty of re-enacting human brain development has precluded… Expand
Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense
- P. Ye, Fred H Rodriguez, +13 authors J. Kolls
- Biology, Medicine
- The Journal of experimental medicine
- 20 August 2001
Bacterial pneumonia is an increasing complication of HIV infection and inversely correlates with the CD4+ lymphocyte count. Interleukin (IL)-17 is a cytokine produced principally by CD4+ T cells,… Expand
Assembly of allosteric macromolecular switches: lessons from PKA
- S. Taylor, Ronit Ilouz, P. Zhang, Alexandr P. Kornev
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 1 October 2012
Protein kinases are dynamic molecular switches that have evolved to be only transiently activated. Kinase activity is embedded within a conserved kinase core, which is typically regulated by… Expand
Radiolabeled Cell Distribution After Intramyocardial, Intracoronary, and Interstitial Retrograde Coronary Venous Delivery: Implications for Current Clinical Trials
- D. Hou, Eyas Al-Shaykh Youssef, +7 authors K. March
- Medicine
- Circulation
- 30 August 2005
Background—Several clinical studies are evaluating the therapeutic potential of delivery of various progenitor cells for treatment of injured hearts. However, the actual fate of delivered cells has… Expand
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
- Tracy L. Flach, Gilbert Ng, +13 authors Y. Shi
- Chemistry, Medicine
- Nature Medicine
- 1 April 2011
As an approved vaccine adjuvant for use in humans, alum has vast health implications, but, as it is a crystal, questions remain regarding its mechanism. Furthermore, little is known about the target… Expand
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses
- R. Zhang, J. Miner, +11 authors M. Diamond
- Biology, Medicine
- Nature
- 10 June 2016
Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is available. We performed a genome-wide CRISPR/Cas9-based screen to identify host genes that, when edited,… Expand
The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery
Research in the last two decades has unveiled an important role for neuroinflammation in the degeneration of the nigrostriatal dopaminergic (DA) pathway that constitutes the pathological basis of the… Expand
Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2*
- P. Zhang, B. Liu, S. W. Kang, M. S. Seo, S. Rhee, L. Obeid
- Biology, Medicine
- The Journal of Biological Chemistry
- 5 December 1997
Thioredoxin peroxidase (TPx) is a member of a newly discovered family of proteins that are conserved from yeast to mammals and to which natural killer enhancing factor belongs. These proteins are… Expand
Innate immunity and pulmonary host defense
Acknowledgments:
DNA‐PKcs, but not TLR9, is required for activation of Akt by CpG‐DNA
- Ana‐Maria Dragoi, X. Fu, +5 authors W. Chu
- Biology, Medicine
- The EMBO journal
- 23 February 2005
CpG‐DNA and its related synthetic CpG oligodeoxynucleotides (CpG‐ODNs) play an important role in immune cell survival. It has been suggested that Akt is one of the CpG‐DNA‐responsive serine/threonine… Expand