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Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
Free radicals are common outcome of normal aerobic cellular metabolism. In-built antioxidant system of body plays its decisive role in prevention of any loss due to free radicals. However, imbalancedExpand
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  • Open Access
Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
Background: The extracranial venous outflow routes in clinically defined multiple sclerosis (CDMS) have not previously been investigated. Methods: Sixty-five patients affected by CDMS, and 235Expand
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  • Open Access
Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells.
Apoptotic death of CD8(+) T cells can be induced by a population of inhibitory myeloid cells that are double positive for the CD11b and Gr-1 markers. These cells are responsible for theExpand
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The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis
Iron stores in the white and deep grey matter in course of multiple sclerosis (MS) have never been explained and could be related to abnormalities in venous drainage, but this possibility has neverExpand
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  • Open Access
A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency.
OBJECTIVE Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by combined stenoses of the principal pathways of extracranial venous drainage, including the internal jugular veinsExpand
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  • Open Access
Anomalous Venous Blood Flow and Iron Deposition in Multiple Sclerosis
  • A. Singh, P. Zamboni
  • Medicine, Chemistry
  • Journal of cerebral blood flow and metabolism…
  • 2 September 2009
Multiple sclerosis (MS) is primarily an autoimmune disorder of unknown origin. This review focuses iron overload and oxidative stress as surrounding cause that leads to immunomodulation in chronicExpand
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The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis.
  • P. Zamboni
  • Medicine
  • Journal of the Royal Society of Medicine
  • 1 November 2006
This article is based on a lecture presented at the Tripartite Meeting, EVF-AVF-UKVF, Royal Society of Medicine, London, 1 July 2006.
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  • Open Access
Trace elements and cognitive impairment: an elderly cohort study.
Dementia is one of the most pressing public health problems with social and economic implication. The form called cognitive impairment non-dementia (CIND)represents a subclinical phase of dementia.Expand
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The chronic cerebrospinal venous insufficiency syndrome
Chronic cerebrospinal venous insufficiency (CCSVI) is a syndrome characterized by stenosies of the internal jugular and/or azygous veins (IJVs-AZ) with opening of collaterals and insufficientExpand
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