• Publications
  • Influence
Large-scale association analysis identifies new risk loci for coronary artery disease
TLDR
An association analysis in CAD cases and controls identifies 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants strongly associated with CAD at a 5% false discovery rate (FDR).
Ancient human genomes suggest three ancestral populations for present-day Europeans
TLDR
It is shown that the great majority of present-day Europeans derive from at least three highly differentiated populations: West European Hunter-Gatherers (WHG), who contributed ancestry to all Europeans but not to Near Easterners; Ancient North Eurasians (ANE); and Early European Farmers (EEF), who were mainly of Near Eastern origin but also harbored WHG-related ancestry.
The Eurasian Heartland: A continental perspective on Y-chromosome diversity
TLDR
This study reports the frequencies of 23 Y-chromosome biallelic polymorphism haplotypes in 1,935 men from 49 Eurasian populations, with a particular focus on Central Asia.
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
TLDR
A GWAS meta-analysis of CAD cases and controls provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.
Association analyses based on false discovery rate implicate new loci for coronary artery disease
TLDR
This approach identified 13 new loci at genome-wide significance, 12 of which were on the previous list of loci meeting the 5% FDR threshold, thus providing strong support that the remaining loci identified by FDR represent genuine signals.
Ancient human genomes suggest three ancestral populations for present-day Europeans
TLDR
It is shown that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians; and early European farmers, who were mainly of Near Eastern origin but also harboured west Europeanhunter-gatherer related ancestry.
Genomic Ancestry of North Africans Supports Back-to-Africa Migrations
TLDR
The genomes of seven North African populations reveal an extraordinarily complex history of migrations, involving at least five ancestral populations, into North Africa, and a gradient of likely autochthonous Maghrebi ancestry that increases from east to west across northern Africa.
Genetically determined height and coronary artery disease.
TLDR
There is a primary association between a genetically determined shorterheight and an increased risk of CAD, a link that is partly explained by the association between shorter height and an adverse lipid profile.
...
1
2
3
4
5
...