P. Zahradka

Publications205
h-index32
Citations3,276
Highly Influential Citations110
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Vascular smooth muscle cell motility: From migration to invasion.
Over the past decade, extensive research has focused on identifying the molecular mechanisms and signal transduction pathways involved in the modulation of vascular smooth muscle cell phenotypes. In… Expand
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Variations in Adipokine Genes AdipoQ, Lep, and LepR are Associated with Risk for Obesity-Related Metabolic Disease: The Modulatory Role of Gene-Nutrient Interactions
Obesity rates are rapidly increasing worldwide and facilitate the development of many related disease states, such as cardiovascular disease, the metabolic syndrome, type 2 diabetes mellitus, and… Expand
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Transactivation of the insulin-like growth factor-I receptor by angiotensin II mediates downstream signaling from the angiotensin II type 1 receptor to phosphatidylinositol 3-kinase.
Angiotensin II (AngII) activates phosphatidylinositol 3-kinase (PI3-kinase), a known effector of receptor tyrosine kinases. Treatment of smooth muscle cells with AngII has also been shown to promote… Expand
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Adipokines and the cardiovascular system: mechanisms mediating health and disease.
This review focuses on the role of adipokines in the maintenance of a healthy cardiovascular system, and the mechanisms by which these factors mediate the development of cardiovascular disease in… Expand
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Angiotensin II activates phosphatidylinositol 3-kinase in vascular smooth muscle cells.
Phosphatidylinositol 3-kinase (PI3K) is an important component of the signal transduction systems activated by tyrosine kinase receptors. It has not been established, however, whether PI3K is also an… Expand
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Inhibition of serotonin-induced vascular smooth muscle cell proliferation by sarpogrelate.
Antiproliferative behavior of sarpogrelate (Anplag, MCI-9042, (+/-)-1-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]-3-(dimethylamino)-2-pro pyl hydrogen succinate hydrochloride), a serotonin 2A (5-HT2A)… Expand
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Cardiotrophin-1: Expression in experimental myocardial infarction and potential role in post-MI wound healing
Cardiotrophin-1 (CT-1), a member of the IL-6 family of cytokines, has been shown to be elevated in the serum of patients with ischemic heart disease and valvular heart disease, and induces… Expand
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A Shuttle Mechanism for DNA‐Protein Interactions
Previously it had been shown that poly(ADP-ribose) polymerase requires DNA for its activity and that this enzyme is auto-poly(ADP-ribosyl)ated. The studies reported here indicate that this… Expand
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Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP.
Phosphatidylinositol 3-kinase (PI3K) is required for smooth muscle cell (SMC) proliferation. This study reports that inhibitors of PI3K also prevent SMC migration and block neointimal hyperplasia in… Expand
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Fibroblast growth factor 2 isoforms and cardiac hypertrophy.
Fibroblast growth factor 2 (FGF-2), a multifunctional polypeptide that affects cell growth and differentiation and becomes upregulated by stress, is expressed as AUG-initiated 18 kDa FGF-2 or… Expand
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