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Vascular smooth muscle cell motility: From migration to invasion.
The characteristics of vascular smooth muscle cell phenotypes as they relate to cell migration are discussed based on insights from recent molecular findings and a central theme is the mechanisms involved in nonpathogenic VSMC migration during tissue repair versus VSMC invasion that leads to the development of vascular diseases.
Variations in Adipokine Genes AdipoQ, Lep, and LepR are Associated with Risk for Obesity-Related Metabolic Disease: The Modulatory Role of Gene-Nutrient Interactions
The findings of single nucleotide polymorphisms in these three genes and their effect on obesity and metabolic disease risk are summarized and studies of gene-nutrient interactions involving adiponectin, leptin, and the leptin receptor are highlighted to emphasize the critical role of diet in susceptible populations.
Angiotensin II activates phosphatidylinositol 3-kinase in vascular smooth muscle cells.
Data indicate that PI3K may operate as a mediator of vascular SMC growth after stimulation with Ang II, and a potential correlation between angiotensin-mediatedPI3K activation and SMCrowth was found using LY294002, a specific inhibitor of PI3k.
Inhibition of serotonin-induced vascular smooth muscle cell proliferation by sarpogrelate.
- S. Sharma, P. Zahradka, D. Chapman, H. Kumamoto, N. Takeda, N. S. Dhalla
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 September 1999
Data indicate that sarpogrelate operates as a specific inhibitor of 5-HT-mediated cell proliferation and is a good candidate for preventing serotonin-induced neointimal hyperplasia.
Transactivation of the insulin-like growth factor-I receptor by angiotensin II mediates downstream signaling from the angiotensin II type 1 receptor to phosphatidylinositol 3-kinase.
Transactivation of the IGF-I receptor is a critical mediator of PI3-kinase activation by AngII but is not required for stimulation of the MAPK cascade, which argues that a paracrine/autocrine loop is not needed.
Cardiotrophin-1: Expression in experimental myocardial infarction and potential role in post-MI wound healing
- D. Freed, M. Moon, A. Borowiec, Stephen C. Jones, P. Zahradka, I. Dixon
- Medicine, BiologyMolecular and Cellular Biochemistry
- 1 December 2003
The results suggest that CT-1, as expressed in post-MI heart, may play an important role in infarct scar formation and ongoing remodeling of the scar as well as fibroblast proliferation and collagen synthesis.
Adipokines and the cardiovascular system: mechanisms mediating health and disease.
- Josette M. Northcott, A. Yeganeh, Carla G. Taylor, P. Zahradka, J. Wigle
- Biology, MedicineCanadian journal of physiology and pharmacology
- 30 May 2012
This review focuses on the role of adipokines in the maintenance of a healthy cardiovascular system, and the mechanisms by which these factors mediate the development of cardiovascular disease in…
The impact of omega-3 polyunsaturated fatty acid supplementation on the incidence of cardiovascular events and complications in peripheral arterial disease: a systematic review and meta-analysis
It is shown that insufficient evidence exists to suggest a beneficial effect of omega-3 PUFA supplementation in adults with peripheral arterial disease with regard to cardiovascular events and other serious clinical outcomes.
Ca2+ mobilization in adult rat cardiomyocytes by angiotensin type 1 and 2 receptors.
Control points in eucaryotic ribosome biogenesis.
This review presents an overview of the mechanisms modulating the production of ribosomal precursor molecules and the rate of Ribosome biogenesis in various biological systems.