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Betulinic acid and its derivatives: a review on their biological properties.
TLDR
A survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990's to the beginning of 2003 is reported. Expand
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
TLDR
Compound N1-(2,6-dimethylphenyl)-N4-(2-hydroxybenzaldehyde) semicarbazone emerged as a prototype with wide spectrum anticonvulsant agent active in five models of seizure with no neurotoxicity and hepatotoxicity. Expand
Synthesis and in vitro and in vivo antimycobacterial activity of isonicotinoyl hydrazones.
TLDR
The results demonstrate the potential and importance of developing new isoniazid derivatives against mycobacterial infections and show the importance of screening for antimycob bacterial activity. Expand
Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives
Abstract On the basis of pharmacophoric modelling studies of existing NNRTIs, a series of isatin β-thiosemicarbazone derivatives was synthesized and evaluated for their anti-HIV activity in HTLV-IIIExpand
Synthesis and anticonvulsant activity of 4-bromophenyl substituted aryl semicarbazones.
TLDR
The essential structural features responsible for interaction with receptor site are established within a suggested pharmacophore and three compounds showed greater protection than sodium valproate. Expand
Synthesis and anticonvulsant and neurotoxicity evaluation of N4-phthalimido phenyl (thio) semicarbazides.
TLDR
The phenyl (thio) semicarbazide derivatives of phthalimido pharmacophore were synthesized and evaluated for their anticonvulsant and neurotoxic properties and exhibited CNS depression and behavioral despair side effects, lesser than the conventional antiepileptic drugs. Expand
An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles.
TLDR
Two atom efficient, green protocol for the synthesis of fifteen 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles and isoniazid was found to be the most potent compound against MTB and MDR-TB. Expand
Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.
TLDR
Two series of pharmacophoric hybrids of phthalimide-GABA-anilides/hydrazones were designed and synthesized and evaluated for their anticonvulsant and neurotoxic properties and most of the compounds were found to be effective in the scSTY and ipPIC models and very few compounds showed protection in thescPTZ model. Expand
Novel ofloxacin derivatives: synthesis, antimycobacterial and toxicological evaluation.
TLDR
The results demonstrate the potential and importance of developing new oxazino quinolone derivatives against mycobacterial infections. Expand
Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides.
TLDR
Various diclofenac acid hydrazones and amides were synthesized and evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis, finding 5d to be the most active compound in vitro with MIC of 0.0383 microM and was more potent than first line antitubercular drug isoniazid. Expand
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