• Publications
  • Influence
Species comparison of pharmacokinetics and metabolism of diltiazem in humans, dogs, rabbits, and rats.
TLDR
The pharmacokinetics and metabolism ofDTZ was investigated in humans, dogs, rabbits, and rats after each species was given a single oral dose of DTZ, and the most abundant metabolites in urine appeared to be MA and deacetyl N,O-didesmethyl diltiazem, although there were considerable inter- and intra-species variations.
Pharmacokinetics of chlorpromazine and key metabolites
TLDR
The data suggest that the high degree of variability in the pharmacokinetics of CPZ is a result of extensive first pass metabolism rather than variation in half life, whereas half life did not appear to be dose dependant.
Pharmacokinetics:Pharmacokinetics and Hypotensive Effect of Diltiazem in Rabbits: Comparison of Diltiazem with its Major Metabolites *
TLDR
A previously established rabbit model has been used to compare the pharmacokinetics and haemodynamic effects of the drug with those of its major metabolites deacetyldiltiazem and deacetyl‐N‐monodemethyldiltsiazem.
Steady-state plasma concentrations of diltiazem and its metabolites in patients and healthy volunteers.
TLDR
An improved high-performance liquid chromatography assay was developed to determine the plasma concentrations of DTZ and seven of its major basic metabolites, including the previously unquantitated Mx and MB, and preliminary results show that steady-state plasma concentrations were higher in the older patients than in young healthy subjects.
Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose
TLDR
There were large inter-individual variations in the plasma concentrations and urinary excretion of DTZ and its metabolites with some parameters differing by more than 20-fold.
Pharmacokinetics and Haemodynamic Effect of Diltiazem in Rats: Effect of Route of Administration
TLDR
The rat has been used as an animal model to determine the effect of the route of administration on the pharmacokinetic and haemodynamic effects of diltiazem.
Pharmacokinetics and metabolism of diltiazem in rabbits after a single intravenous or single oral administration
TLDR
The rabbit is a suitable animal model to investigate the kinetics and metabolism of DTZ and its metabolites, and the results showed that the metabolism and disposition in rabbits was similar to that of humans.
High-performance liquid chromatographic assay of diltiazem and six of its metabolites in plasma: application to a pharmacokinetic study in healthy volunteers.
A sensitive and specific reversed-phase high-performance liquid chromatographic assay for simultaneous determination of plasma concentrations of diltiazem and six of its metabolites known to occur in
...
...