• Publications
  • Influence
Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells.
  • P. Yaswen, M. Stampfer
  • Medicine, Biology
  • The international journal of biochemistry & cell…
  • 1 November 2002
Limits on the proliferative potential of cultured normal human cells may be consequences of pathways that exist to suppress tumorigenicity. Human mammary epithelial cells (HMEC) employ severalExpand
  • 103
  • 8
Cancer and aging: the importance of telomeres in genome maintenance.
Telomeres are the specialized DNA-protein structures that cap the ends of linear chromosomes, thereby protecting them from degradation and fusion by cellular DNA repair processes. In vertebrateExpand
  • 113
  • 6
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression
Triple-negative breast cancer (TNBC), in which cells lack expression of the estrogen receptor (ER), the progesterone receptor (PR) and the ERBB2 (also known as HER2) receptor, is the breast cancerExpand
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Reinforcing targeted therapeutics with phenotypic stability factors
  • P. Yaswen
  • Medicine, Biology
  • Cell cycle
  • 18 November 2014
Deregulated cell cycle progression can often be traced to intrinsic defects in specific regulatory proteins in cancer cells. Knowledge of these primary defects has led to targeted approaches thatExpand
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Effects of sequence of thioated oligonucleotides on cultured human mammary epithelial cells.
We have compared the effects of a number of different oligonucleotides on the growth and morphology of normal finite life span and immortally transformed human mammary epithelial cells. TheExpand
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Designing a broad-spectrum integrative approach for cancer prevention and treatment.
Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targetedExpand
  • 106
  • 2
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Protein product of a human intronless calmodulin-like gene shows tissue-specific expression and reduced abundance in transformed cells.
The recently identified NB-1 mRNA is transcribed from a single intronless gene, previously thought to be an unexpressed calmodulin pseudogene. Although expression levels of the three known humanExpand
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Oncogene-Induced Senescence Pathways Weave an Intricate Tapestry
The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouseExpand
  • 126
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Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells.
A human cDNA library obtained from cultured normal mammary epithelial cells (HMECs) was searched by subtractive hybridization for genes whose decrease in expression might be relevant to epithelialExpand
  • 52
  • 1
Therapeutic targeting of replicative immortality
One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire sequential aberrations that can fuelExpand
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