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Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.
TLDR
A new nomenclature for HCV variants is proposed in this communication that reflects the two-tiered nature of sequence differences between different viral isolates and describes criteria that would enable new variants to be assigned within the classification as they are discovered. Expand
Geographical distribution of hepatitis C virus genotypes in blood donors: an international collaborative survey.
TLDR
The frequency of infection with the six classified major genotypes of hepatitis C virus (HCV) was investigated in 447 infected volunteer blood donors from the following nine countries, suggesting that vaccines based on these proteins need to be multivalent and perhaps specifically adapted for different geographical regions. Expand
Detection of a novel DNA virus (TTV) in blood donors and blood products.
TLDR
The frequency of TTV viraemia in UK blood donors, and the extent to which TTV contaminates blood products such as factor VIII and IX clotting factors is investigated, finding transmission through transfusion of blood components may have occurred extensively. Expand
Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants.
TLDR
Phylogenetic analysis revealed the existence of three distinct groups of sequences that corresponded to the recently described HCV types 1 and 2 variants, while viral sequences detected in around a third of the blood donors formed a separate phylogenetic group that probably represents infection with a novel virus species. Expand
Detection of a novel DNA virus (TT virus) in blood donors and blood products
TLDR
The frequency of TTV viraemia in UK blood donors, and the extent to which TTV contaminates blood products such as factor VIII and IX clotting factors, is investigated. Expand
The origin of hepatitis C virus genotypes.
TLDR
It is shown here that the common ancestor of different types of hepatitis C virus (HCV) is older than previously thought, andimation of the time of origin of the major HCV genotypes (types 1-6) is problematic, but data and analogy with other viruses suggest that divergence occurred at least 500-2000 years ago. Expand
Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification. The International HCV Collaborative Study Group.
TLDR
The existence of great diversity within a single genotype was also found amongst type 3 sequences in the Indian subcontinent, amongst type 4 variants in Central Africa and the Middle East, and amongst type variants in Nigeria. Expand
Infection with hepatitis G virus among recipients of plasma products
TLDR
The prevalence of persistent infection of HGV and HCV in patients exposed to non-virus-inactivated pooled blood products associated with transmission of HCV is investigated and virus inactivation of blood products substantially reduced or eliminated contamination by HGV RNA sequences. Expand
Sequence variability in the 5' non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity.
TLDR
The specific nucleotide substitutions in the 5' NCR that differentiate each of the four HCV types can be detected by restriction enzyme cleavage, providing a rapid and reliable method for virus typing. Expand
Survey of type 6 group variants of hepatitis C virus in Southeast Asia by using a core-based genotyping assay.
TLDR
A new genotyping assay based upon RFLP of sequences amplified from the more variable core region to investigate the distribution of type 6 group variants in southeast (SE) Asia suggests a relatively limited distribution. Expand
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