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The angiosuppressive effects of 20(R)- ginsenoside Rg3.
Aberrant angiogenesis is an essential step for the progression of solid tumors. Thus anti-angiogenic therapy is one of the most promising approaches to control tumor growth. In this study, we… Expand
Angiogenesis: from plants to blood vessels.
- T. Fan, J. Yeh, K. Leung, P. Y. Yue, R. N. Wong
- Trends in pharmacological sciences
- 1 June 2006
Angiogenesis is a major pathological component of diseases such as cancer and coronary heart disease. Although major advances have been made and encouraging clinical results obtained, safer and more… Expand
The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo
Angiogenesis plays an important role in a wide range of physiological processes such as wound healing and fetal development. Many diseases are associated with imbalances in regulation of… Expand
The ginsenoside protopanaxatriol protects endothelial cells from hydrogen peroxide-induced cell injury and cell death by modulating intracellular redox status.
- Hoi-Hin Kwok, W. Y. Ng, Mildred S. Yang, N. Mak, R. Wong, P. Y. Yue
- Chemistry, Medicine
- Free radical biology & medicine
- 1 February 2010
Ginsenosides, the active components of the famous Chinese herb ginseng, have been suggested to possess cardiovascular-protective effects. The mechanism of ginsenosides is believed to be associated… Expand
Use of three-color cDNA microarray experiments to assess the therapeutic and side effect of drugs
A new kind of graph, hexaMplot, is constructed to illustrate the meaningful expression patterns of normal-disease-drug in three-color experiment. Expand
Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides
In Chinese medicine, ginseng (Panax ginseng C.A. Meyer) has long been used as a general tonic or an adaptogen to promote longevity and enhance bodily functions. It has also been claimed to be… Expand
Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.
Methyl protodioscin is a furostanol bisglycoside with antitumor properties. The present study investigated its effects on human chronic myelogenous leukemia K562 cells. Cell cycle analysis showed… Expand
A Simplified Method for Quantifying Cell Migration/Wound Healing in 96-Well Plates
Cell migration plays a key role in both normal physiological and pathological conditions. The study of cell migration and its underlying mechanisms is of great significance in various fields of… Expand
Role of microRNA-214 in ginsenoside-Rg1-induced angiogenesis.
- L. Chan, P. Y. Yue, N. Mak, R. Wong
- Biology, Medicine
- European journal of pharmaceutical sciences…
- 5 November 2009
MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional gene modulators. Ginsenoside-Rg1, one of the active components of ginseng, has been confirmed as an angiogenesis inducer.… Expand
The Anti-Angiogenic Effect of Sinomenine
Sinomenine is an alkaloid extracted from the Chinese medicinal plant, Sinomenium acutum, which has been utilized to treat rheumatoid arthritis (RA) in China for over 2000 years. Sinomenine has been… Expand