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Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation
It is reported that the unconventional linkages are abundant in vivo and that all non-K63 linkages may target proteins for degradation, and that unconventional polyubiquitin chains are critical for ubiquitin-proteasome system function. Expand
Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
It is indicated that lipin is required for normal adipose tissue development, and provide a candidate gene for human lipodystrophy. Expand
Activated Expression of an Arabidopsis HD-START Protein Confers Drought Tolerance with Improved Root System and Reduced Stomatal Density[W][OA]
Drought is one of the most important environmental constraints limiting plant growth and agricultural productivity. To understand the underlying mechanism of drought tolerance and to identify genesExpand
Relative and Absolute Quantification of Postsynaptic Density Proteome Isolated from Rat Forebrain and Cerebellum*S
This study delineates a crucial molecular difference between forebrain and cerebellar PSDs and provides a quantitative framework for measuring the molecular stoichiometry of the PSD, and demonstrates that the absolute quantification method is well suited for targeted quantitative proteomic analysis. Expand
Virus infection improves drought tolerance.
It is shown that virus infection improves plant tolerance to abiotic stress, which correlates with increased osmoprotectant and antioxidant levels in infected plants. Expand
Computational Estimation and Experimental Verification of Off-Target Silencing during Posttranscriptional Gene Silencing in Plants1[W][OA]
The results suggest that a high risk of off-target gene silencing exists during PTGS in plants, and a publicly available Web-based computational tool called siRNA Scan is useful to design better constructs for PTGS by minimizing off-targets in both plants and animals. Expand
Acetoin Metabolism in Bacteria
  • Zijun Xiao, P. Xu
  • Biology, Medicine
  • Critical reviews in microbiology
  • 1 January 2007
This is the first integrated review on acetoin metabolism in bacteria, especially with regard to catabolic aspects, and the relationship between the two conflicting acetoin cleavage pathways is discussed. Expand
Structure dissection of human progranulin identifies well‐folded granulin/epithelin modules with unique functional activities
The functionally active and structurally well‐characterized human hGrnA offers a unique opportunity for detailed structure–function studies of these important GEM proteins as novel members of mammalian growth factors. Expand
Enhanced 2,3-butanediol production by Klebsiella pneumoniae SDM
Enhanced 2,3-butanediol production was carried out by Klebsiella pneumoniae SDM and the maximum BD concentration of 150 g/l at 38 h with a diol productivity was obtained by the constant residual glucose concentration feeding strategy, setting new records on BD fermentation. Expand
Overexpression of the AP2/EREBP transcription factor OPBP1 enhances disease resistance and salt tolerance in tobacco
Results suggest that OPBP1 might be a transcriptional regulator capable of regulating expression in sets of stress-related genes. Expand