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Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells.
Cancer and embryonic stem cells exhibit similar behavior, including immortal, undifferentiated, and invasive activities. Here, we show that in clinical samples bladder tumors with intense expressionExpand
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Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells
Although histone deacetylase inhibitors (HDACis) are emerging as a new class of anticancer agents, the mechanism of tumor-selective killing by HDACi is not well understood. We used suppression ofExpand
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Prothymosin α overexpression contributes to the development of pulmonary emphysema
Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role ofExpand
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Tumor-Selective Replication of an Oncolytic Adenovirus Carrying Oct-3/4 Response Elements in Murine Metastatic Bladder Cancer Models
Purpose: Oncolytic adenoviruses are attractive therapeutics for cancer because they selectively replicate in tumors. However, targeting tumor metastasis remains a major challenge for currentExpand
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Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis
Background The influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how maritalExpand
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Current obstetric guidelines on thromboprophylaxis in the United Kingdom: evidence based medicine?
In the United Kingdom, the national guidance from Royal College of Obstetricians and Gynaecologists (RCOG) and National Institute for Health and Clinical Excellence (NICE) encourages the use of lowExpand
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Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis
Aims/hypothesisPre-eclampsia is a pregnancy-specific multisystem disorder and a state of physiological insulin resistance. Our aim was to systematically evaluate and quantify the evidence on theExpand
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Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies
ABSTRACT Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placentalExpand
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Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer
Cancer cells initially characterized as sensitive to chemotherapy may acquire resistance to chemotherapy and lead to tumor recurrence through the expansion of drug-resistant population. AcquisitionExpand
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Over‐expression of prothymosin‐α antagonizes TGFβ signalling to promote the development of emphysema
Emphysema, a major consequence of chronic obstructive pulmonary disease (COPD), is characterized by the permanent airflow restriction resulting from enlargement of alveolar airspace and loss of lungExpand
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