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Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis
TLDR
Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b, and the development of novel prevention and treatment strategies should be accelerated as a priority. Expand
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.
TLDR
The zoster vaccine markedly reduced morbidity from herpes zoster and postherpetic neuralgia among older adults and significantly reduced the burden of illness due to herpesZoster. Expand
Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children.
TLDR
Human metapneumovirus infection is a leading cause of respiratory tract infection in the first years of life, with a spectrum of disease similar to that of respiratory syncytial virus. Expand
Rates of hospitalization for respiratory syncytial virus infection among children in medicaid.
TLDR
Children with bronchopulmonary dysplasia have high rates of RSV hospitalization until 24 months of age, and after the first year of life, children with congenital heart disease or prematurity have rates no higher than that of children at low risk who are <12 months old. Expand
The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children.
TLDR
Healthy children younger than one year of age are hospitalized for illness attributable to influenza at rates similar to those for adults at high risk for influenza. Expand
The histopathology of fatal untreated human respiratory syncytial virus infection
TLDR
Airway obstruction was a prominent feature in all cases attributed to epithelial and inflammatory cell debris mixed with fibrin, mucus, and edema, and compounded by compression from hyperplastic lymphoid follicles, which inform the understanding of RSV pathogenesis and may facilitate the development of new approaches for prevention and treatment. Expand
Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis
TLDR
The role of influenza in childhood mortality from ALRI is estimated by combining incidence estimates with case fatality ratios from hospital-based reports and identifying studies with population-based data for influenza seasonality and monthly ALRI mortality. Expand
Primary respiratory syncytial virus infection in mice
TLDR
This model will serve as the basis for investigating immunodeterminants of recovery and protection from RSV infection and lung histology of older mice infected with RSV shows bronchiolitis and increased number of lymphocytes and macrophages in alveolar spaces. Expand
Role of IgA versus IgG in the Control of Influenza Viral Infection in the Murine Respiratory Tract1
TLDR
Both Abs are important, with plasma IgG Ab serving as the back-up for secretory IgA-mediated protection in the nasal compartment, and IgG being the dominant Ab in protection of the lung. Expand
Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice.
TLDR
It is postulated that antibody is an illness-sparing mechanism for protecting mice from RSV infection, and that T lymphocytes are an important determinant of illness. Expand
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