• Publications
  • Influence
Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats.
  • S. Lau, P. Woo, +7 authors K. Yuen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 27 September 2005
In a surveillance study for CoV in noncaged animals from the wild areas of the Hong Kong Special Administration Region, a CoV closely related to SARS-CoV is identified from 23 (39%) of 59 anal swabs of wild Chinese horseshoe bats by using RT-PCR and the presence of a 29-bp insertion in ORF 8 of bat-SARS- coV genome suggests that it has a common ancestor with civet SARS -CoV. Expand
Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia
The data support the existence of a novel group 2 coronavirus associated with pneumonia in humans, CoV-HKU1, from a 71-year-old man with pneumonia who had just returned from Shenzhen, China. Expand
Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses
It appears that bats and birds, the warm blooded flying vertebrates, are ideal hosts for the coronavirus gene source and birds for Gammacoronavirus and Deltacor onavirus, to fuel coronav virus evolution and dissemination. Expand
Commentary: Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group
During the summer of 2012, in Jeddah, Saudi Arabia, a hitherto unknown coronavirus (CoV) was isolated from the sputum of a patient with acute pneumonia and renal failure ([1][1], [2][2]). The isolateExpand
Coronavirus Diversity, Phylogeny and Interspecies Jumping
The present evidence supports that bat coronaviruses are the gene pools of group 1 and 2 coronaviraluses, whereas bird coronavirus are the genes of group 3 coronavIRuses. Expand
Clinical Features and Complete Genome Characterization of a Distinct Human Rhinovirus (HRV) Genetic Cluster, Probably Representing a Previously Undetected HRV Species, HRV-C, Associated with Acute
  • S. Lau, C. Yip, +6 authors K. Yuen
  • Medicine, Biology
  • Journal of Clinical Microbiology
  • 5 September 2007
It is revealed that a newly identified HRV species, HRV-C, is circulating worldwide and is an important cause of febrile wheeze and asthmatic exacerbations in children requiring hospitalization. Expand
Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease
Developing an effective camel MERS-CoV vaccine and implementing appropriate infection control measures may control the continuing epidemic. Expand
Coronavirus Genomics and Bioinformatics Analysis
Coronaviruses possess the largest genomes among all known RNA viruses, with G + C contents varying from 32% to 43%. Expand
Comparative Analysis of Twelve Genomes of Three Novel Group 2c and Group 2d Coronaviruses Reveals Unique Group and Subgroup Features
The high Ka/Ks ratio of NS7a and NS7b in bat-CoV HKU9 implies that these two group 2d-specific genes are under high selective pressure and hence are rapidly evolving, and the four subgroups of group 2 coronavirus probably originated from a common ancestor. Expand
Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats
  • P. Woo, S. Lau, +11 authors K. Yuen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 19 March 2012
Histological examination of necropsy tissues in two FmoPV-positive cats revealed interstitial inflammatory infiltrate and tubular degeneration/necrosis in kidneys, with decreased cauxin expression in degenerated tubular epithelial cells, compatible with tubulointerstitial nephritis (TIN). Expand