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Funnels, pathways, and the energy landscape of protein folding: A synthesis
TLDR
The work unifies several previously proposed ideas concerning the mechanism protein folding and delimits the regions of validity of these ideas under different thermodynamic conditions. Expand
The energy landscapes and motions of proteins.
TLDR
The concepts that emerge from studies of the conformational substates and the motions between them permit a quantitative discussion of one simple reaction, the binding of small ligands such as carbon monoxide to myoglobin. Expand
Theory of protein folding: the energy landscape perspective.
TLDR
The energy landscape theory of protein folding suggests that the most realistic model of a protein is a minimally frustrated heteropolymer with a rugged funnel-like landscape biased toward the native structure. Expand
Theory of protein folding.
TLDR
This work states that proteins have a rugged funnel-like landscape biased toward the native structure as a result of evolution, and connecting theory and simulations of minimalist models with experiments has completely revolutionized the understanding of the underlying mechanisms that control protein folding. Expand
Theory of structural glasses and supercooled liquids.
We review the random first-order transition theory of the glass transition, emphasizing the experimental tests of the theory. Many distinct phenomena are quantitatively predicted or explained by theExpand
Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding
We synthesized tiny stable silver nanoparticles (2.6 f 1 .I nm) and used its small surface area and functional groups to control single molecule detection (SMD) volumes on single nanoparticles. TheseExpand
Speeding molecular recognition by using the folding funnel: the fly-casting mechanism.
TLDR
It is found that a relatively unstructured protein molecule can have a greater capture radius for a specific binding site than the folded state with its restricted conformational freedom. Expand
Self-regulating gene: an exact solution.
TLDR
An exact steady-state solution of the stochastic equations governing the behavior of a gene regulated by a self-generated proteomic atmosphere reveals deviations from the commonly used Ackers et al approximation, allowing anticooperative behavior in the "nonadiabatic" limit of slow binding and unbinding rates. Expand
Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins
TLDR
This work presents a model for global structural transformations, such as allostery, that involve large-scale motion and possible partial unfolding, illustrating the method with the conformational transition of adenylate kinase. Expand
DIFFUSIVE DYNAMICS OF THE REACTION COORDINATE FOR PROTEIN FOLDING FUNNELS
TLDR
The quantitative description of model protein folding kinetics using a diffusive collective reaction coordinate is examined and Analytic folding calculations, using simple diffusive rate theory, agree extremely well with the full simulation results. Expand
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