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GAS2L3, a target gene of the DREAM complex, is required for proper cytokinesis and genomic stability
TLDR
It is found that GAS2L3 localizes to the spindle midzone and the midbody during anaphase and cytokinesis, respectively, which contributes to the understanding of how DREAM regulates cytokinesIS. Expand
An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma
TLDR
It is demonstrated that MMB is required for tumor formation in a mouse model of lung cancer driven by oncogenic K-RAS and a requirement for the mitotic kinesin KIF23, a key target gene of MMB, in tumorigenesis is identified. Expand
The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer
TLDR
It is shown that the depletion of PRC1 results in a strong increase in bi- and multinuclear cells due to defects in cytokinesis, which ultimately leads to apoptosis and senescence. Expand
Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy
TLDR
It is demonstrated that six mitotic kinesins and two microtubule-associated non-motor proteins (MAPs) CEP55 and PRC1 are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cells. Expand
The GAR domain of GAS2L3 mediates binding to the chromosomal passenger complex and is required for localization of GAS2L3 to the constriction zone during abscission
TLDR
Biochemical assays suggest that GAS2L3 is a downstream effector of the CPC during cytokinetic abscission, and the GAR domain of GAS1L2 is required for localization of G AS2L 3 to the constriction zone. Expand