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Kynurenine is an endothelium-derived relaxing factor produced during inflammation
TLDR
Results identify tryptophan metabolism by Ido as a new pathway contributing to the regulation of vascular tone and the control of blood pressure in spontaneously hypertensive rats.
Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities.
TLDR
The various ways in which ROS can influence endothelial function and dysfunction are outlined, the redox mechanisms involved are described, and approaches for preventing endothelial dysfunction are discussed that may highlight future therapeutic opportunities in the treatment of cardiovascular disease.
The peroxidase activity of a hemin--DNA oligonucleotide complex: free radical damage to specific guanine bases of the DNA.
TLDR
Experimental findings support the hypothesis that the interaction of specific guanines of PS2.M with the bound hemin cofactor might contribute to the superior peroxidative activity of the PS 2.M--hemin complex.
Oxidation of High Density Lipoproteins
TLDR
It is concluded that the oxidation of specific Met residues of apoAI and apoAII to Met(O) plays a significant role in the 2-electron reduction of hydroperoxides of cholesteryl esters and phosphatidylcholine associated with human HDL.
Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles
TLDR
It is shown that infused negatively charged, immune-modifying microparticles, derived from polystyrene, microdiamonds, or biodegradable poly(lactic-co-glycolic) acid, were taken up by inflammatory monocytes, in an opsonin-independent fashion, via the macrophage receptor with collagenous structure (MARCO).
Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging
TLDR
2-electron rather than radical oxidants as important contributors to atherogenesis are indicated, and novel lead compounds for therapeutic intervention against atherosclerotic diseases are pointed to.
α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II
TLDR
It is proposed that α-TOS displaces UbQ in CII causing electrons generated by SDH to recombine with molecular oxygen to yield ROS, highlighting CII, a known tumour suppressor, as a novel target for cancer therapy.
Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II*
TLDR
It is proposed that mitochondrial targeting of VES with an 11-carbon chain localizes the agent into an ideal position across the interface of the mitochondrial inner membrane and matrix, optimizing its biological effects as an anti-cancer drug.
Neuroglobin overexpression in cultured human neuronal cells protects against hydrogen peroxide insult via activating phosphoinositide-3 kinase and opening the mitochondrial K(ATP) channel.
TLDR
Neuroglobin's ability to bolster the intracellular pool of ATP in response to added H(2)O( 2) is central to the preservation of cytoskeletal integrity and cell viability.
Protective effect of a synthetic anti‐oxidant on neuronal cell apoptosis resulting from experimental hypoxia re‐oxygenation injury
TLDR
Addition of a phenolic anti‐oxidant, bisphenol (BP), prior to H/R injury, inhibited ROS production and gene regulation and significantly decreased neuronal cell apoptosis, indicating that BP has the potential to act as a neuro‐protective drug.
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