• Publications
  • Influence
Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS
  • P. Willner
  • Psychology, Medicine
  • Neuropsychobiology
  • 1 August 2005
TLDR
There is overwhelming evidence that under appropriate experimental conditions, CMS can cause antidepressant-reversible depressive-like effects in rodents; however, the ‘anomalous’ profile that is occasionally reported appears to be a genuine phenomenon, and these two sets of behavioural effects appear to be associated with opposite patterns of neurobiological changes. Expand
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
  • P. Willner
  • Psychology, Medicine
  • Psychopharmacology
  • 2 June 1997
TLDR
Overall, the CMS procedure appears to be at least as valid as any other animal model of depression, and can be used to study problems that are extremely difficult to address by other means. Expand
Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
TLDR
Rats exposed chronically to a variety of mild unpredictable stressors showed a reduced consumption of and preference for saccharin or sucrose solutions and DMI reduced blood corticosterone and glucose levels, but stress did not significantly alter either measure. Expand
The validity of animal models of depression
  • P. Willner
  • Psychology, Medicine
  • Psychopharmacology
  • 2004
TLDR
The models with the highest overall validity are the intracranial self-stimulation, chronic stress and learned helplessness models in rats, and the primate separation model. Expand
Chronic mild stress-induced anhedonia: A realistic animal model of depression
TLDR
The validity of chronic mild stress-induced anhedonia as an animal model of depression is reviewed, and the evidence that changes in hedonic responsiveness in this model are mediated by changes in the sensitivity of dopamine D2 receptors in the nucleus accumbens is reviewed. Expand
The chronic mild stress (CMS) model of depression: History, evaluation and usage
  • P. Willner
  • Psychology, Medicine
  • Neurobiology of Stress
  • 24 August 2016
TLDR
An update on the validity and reliability of the CMS model, and recent data on the neurobiological basis of CMS effects and the mechanisms of antidepressant action are reviewed: the volume of this research may be unique in providing a comprehensive account of antidepressants action within a single model. Expand
The neurobiology of depression and antidepressant action
TLDR
It is suggested that the problem of depression comprises three sub-problems: first episodes in people with low vulnerability ('simple' depressions); an increase in vulnerability and autonomy from stress that develops over episodes of depression (kindling); and factors that confer vulnerability to a first episode (a depressive diathesis). Expand
A comparison of two alcohol craving questionnaires.
TLDR
The results support a multifactorial account of alcohol craving, and indicate that the DAQ has some advantages over the ACQ as a research tool. Expand
The validity of animal models of predisposition to depression.
TLDR
This paper reviews the validity of the available models of predisposition to depression, which derive from genetics, genomics, developmental manipulations, and brain lesioning, and compares the performance of the different models using a novel scoring system. Expand
Animal models of depression: an overview.
  • P. Willner
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 1990
TLDR
La revue est centree sur la validite de ces modeles animaux, sur les informations qu'ils ont permis de produire and sur les contributions qu'they sont susceptibles d'apporter dans le futur. Expand
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