Coagulation changes in individuals with sickle cell trait
- M. Westerman, D. Green, P. Williamson
- MedicineAmerican journal of hematology/oncology
- 1 February 2002
The study shows that individuals with Hb AS have increased coagulation activity, with d‐dimers, TAT, and F1.2 being consistent indicators, and suggests that monocytosis, with the possible expression of monocyte‐derived tissue factor, and the associated hypercoagulable state are driven by disease severity.
Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes
- B. Verhoven, R. Schlegel, P. Williamson
- BiologyJournal of Experimental Medicine
- 1 November 1995
Flow cytometric analysis of transbilayer lipid movements in T lymphocytes undergoing apoptosis reveals that downregulation of the adenosine triphosphate- dependent amino-phospholipid translocase and activation of a nonspecific lipid scramblase are responsible for PS reaching the surface from its intracellular location.
Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p*♦
- G. Lenoir, P. Williamson, C. F. Puts, J. Holthuis
- Biology, ChemistryJournal of Biological Chemistry
- 2 May 2009
The data indicate that Cdc50 proteins are integral components of the P4-ATPase transport machinery, and acquisition of these subunits may have been a crucial step in the evolution of flippases from a family of cation pumps.
Differential expression of putative transbilayer amphipath transporters.
- M. S. Halleck, J. R. Lawler JF, R. Schlegel
- BiologyPhysiological Genomics
- 11 November 1999
Results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipath transporters.
Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane.
- E. Bevers, P. Williamson
- BiologyPhysiological Reviews
- 1 April 2016
What is known about the mechanism of PS exposure at the surface of the plasma membrane of cells, how actors in the extracellular milieu sense surface exposed PS, and how this recognition is translated to downstream consequences ofPS exposure are discussed are discussed.
Multiple systems for recognition of apoptotic lymphocytes by macrophages.
- D. Pradhan, S. Krahling, P. Williamson, R. Schlegel
- BiologyMolecular Biology of the Cell
- 1 May 1997
It is demonstrated here that bothactivated and unactivated macrophages recognize PS, but with different receptor systems, suggesting that PS exposure on the surface of apoptotic lymphocytes generates a complex and evolving signal recognized by different receptor complexes on activated and un activated macrophage.
Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes.
- Xiaoxuan Fan, S. Krahling, Douglas Smith, P. Williamson, R. Schlegel
- BiologyMolecular Biology of the Cell
- 1 June 2004
This work has shown that annexin bridging is vectorial, because annexin is bound to PS molecules on targets but not on macrophages, suggesting annexins serve as both ligand and receptor in promoting phagocytosis.
Merocyanine 540, a fluorescent probe sensitive to lipid packing.
- P. Williamson, K. Mattocks, R. Schlegel
- Chemistry, BiologyBiochimica et Biophysica Acta
- 27 July 1983
Presence of human immunodeficiency virus DNA in laser smoke
- M. Baggish, Bernard J. Polesz, D. Joret, P. Williamson, A. Refai
- Biology, MedicineLasers in Surgery and Medicine
- 1991
Concentrated tissue culture pellets infected with human immunodeficiency virus (HIV) containing 1 ± 107 cells/ml were vaporized by means of a carbon dioxide laser, and particulate debris obtained from the silastic collection tubing was positive from proviral HIV DNA in both immediately sampled and day 14 cultured material.
Antiphospholipid antibodies, proteins C and S, and coagulation changes in sickle cell disease.
- M. Westerman, D. Green, P. Williamson
- Medicine, BiologyJournal of Laboratory and Clinical Medicine
- 1 October 1999
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