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The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis
Interleukin 15 (IL–15) is a novel cytokine with interleukin–2–like activity. It is also a potent T–lymphocyte chemoattractant. Rheumatoid arthritis (RA) is a chronic inflammatory diseaseExpand
Chemotaxis and inflammation
It is known that neutrophils, as well as eosinophils, lymphocytes and basophils, migrate into the site of anaphylactic reactions in skin. The cellular infiltration migth produce a prolongedExpand
Effects of staphylococcal products on locomotion and chemotaxis of human blood neutrophils and monocytes.
The effects of staphylococcal products as chemo-attractants for human blood neutrophils and monocytes and as inhibitors of locomotion of these cells were studied with bacterial cells, cultureExpand
Chemoattraction of human blood T lymphocytes by interleukin-15
Recombinant interleukin (IL)-15, derived from a simian kidney epithelial cell line, is a chemoattractant for human blood T lymphocytes judged by its ability to increase the proportion of cells inExpand
Identification of IL-8 as a locomotor attractant for activated human lymphocytes in mononuclear cell cultures with anti-CD3 or purified protein derivative of Mycobacterium tuberculosis.
On culture of human blood mononuclear cells for 24 to 48 h with anti-CD3 (aCD3) or purified protein derivative of Mycobacterium tuberculosis, chemoattractants are released into the medium whichExpand
Assays of leukocyte locomotion and chemotaxis.
  • P. Wilkinson
  • Biology, Medicine
  • Journal of immunological methods
  • 1 July 1998
This review discusses the range of methods which are currently available for measuring locomotion and chemotaxis of leukocytes in vitro, their history, and some definitions of terms. Assays of theExpand
The chemoattractant activity of rheumatoid synovial fluid for human lymphocytes is due to multiple cytokines
The majority of synovial fluids from 29 rheumatoid arthritis patients were strongly attractive for normal blood lymphocytes judged by assays of polarization and collagen gel invasion. WhileExpand
Uncoupling of stem cell inhibition from monocyte chemoattraction in MIP‐1alpha by mutagenesis of the proteoglycan binding site.
We have studied the role of proteoglycans in the function of Macrophage Inflammatory Protein‐1 alpha (MIP‐1alpha), a member of the proteoglycan binding chemokine family. Sequence and peptide analysisExpand
Heterogeneity of peripheral blood monocyte populations in human immunodeficiency virus-1 seropositive patients.
Monocytes from human immunodeficiency virus (HIV) patients have an increased heterogeneity of phenotype and function. In a study of 120 HIV patients we have demonstrated that they have normalExpand
Aggregation of the chemokine MIP-1 alpha is a dynamic and reversible phenomenon. Biochemical and biological analyses.
Macrophage inhibitory protein (MIP)-1 alpha is a potent inhibitor of hemopoietic stem cell proliferation and is a member of a family of pro-inflammatory mediators, the chemokine family. This moleculeExpand