• Publications
  • Influence
Interventions to improve antibiotic prescribing practices for hospital inpatients.
TLDR
The results show that interventions to improve antibiotic prescribing to hospital inpatients are successful, and can reduce antimicrobial resistance or hospital acquired infections.
EFNS guidelines on pharmacological treatment of neuropathic pain
TLDR
Evaluated trials provide level A evidence for the efficacy of tricyclic antidepressants, gabapentin, pregabalin and opioids, with a large number of class I trials, followed by topical lidocaine and the newer antidepressants venlafaxine and duloxetine.
Long-term opioid management for chronic noncancer pain.
TLDR
Weak evidence suggests that patients who are able to continue opioids long-term experience clinically significant pain relief, and whether quality of life or functioning improves is inconclusive, due to an insufficient quantity of evidence for oral administration studies and inconclusive statistical findings for transdermal and intrathecal administration studies.
Pregabalin for acute and chronic pain in adults.
TLDR
Efficacy was demonstrated for dichotomous outcomes equating to moderate or substantial pain relief, alongside lower rates for lack of efficacy discontinuations with increasing dose, in patients with postherpetic neuralgia and painful diabetic neuropathy.
Interventions to improve antibiotic prescribing practices for hospital inpatients.
TLDR
The effectiveness of professional interventions that, alone or in combination, are effective in antibiotic stewardship for hospital inpatients are estimated and the impact of these interventions on reducing the incidence of antimicrobial-resistant pathogens or Clostridium difficile infection is evaluated.
Pharmacotherapy for the prevention of chronic pain after surgery in adults.
TLDR
Meta-analysis suggested a modest but statistically significant reduction in the incidence of chronic pain after surgery following treatment with ketamine but not gabapentin or pregabalin, and available evidence does not support the efficacy of gabAPentin, pregABalin, non-steroidal anti-inflammatories, intravenous steroids, oral NMDA blockers or inhaled nitrous oxide for the prevention of chronic postoperative pain.
Anticonvulsant drugs for management of pain: a systematic review
TLDR
Systematic review of randomised controlled trials of anticonvulsants for acute, chronic, or cancer pain identified by using Medline, by hand searching, by searching reference lists, and by contacting investigators found anticonVulsants were effective for trigeminal neuralgia and diabetic neuropathy and for migraine prophylaxis.
Gabapentin for chronic neuropathic pain and fibromyalgia in adults.
TLDR
Gabapentin provides pain relief of a high level in about a third of people who take if for painful neuropathic pain, and more conservative estimates of efficacy resulted from using better definitions of efficacy outcome at higher, clinically important, levels.
Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs
TLDR
Topical non-steroidal anti-inflammatory drugs are effective in relieving pain in acute and chronic conditions and local and systemic adverse events and withdrawal from the study related to the drug had a low incidence and were no different from placebo.
ENHANCED GLUCOSE CONTROL FOR PREVENTING AND TREATING DIABETIC NEUROPATHY
TLDR
A meta-analysis of two studies in type 1 diabetes found a significantly reduced risk of developing clinical neuropathy in those with enhanced glucose control, but there is a big BUT, both types of diabetic participants also had a significant increase in severe adverse events including hypoglycemic events.
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