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The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis
A functional screen identified MARK4 as a positive regulator of axonemal extension and ciliogenesis via its interaction with the mother centriolar protein ODF2.
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Functional importance of the C‐terminus of the human norepinephrine transporter
Three C‐terminal variants of the human norepinephrine transporter (hNET) are known: the wild‐type hNET in which exon 14 encodes the last seven amino acids and two variants with either three or 18Expand
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Cloning and functional characterization of the human norepinephrine transporter gene promoter
Summary. The norepinephrine transporter (NET) plays a critical role in brain norepinephrine homeostasis and is a target for antidepressants and drugs of abuse. We have analyzed the 5'flankingExpand
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Molecular and Structural Analysis of a Continuous Birch Profilin Epitope Defined by a Monoclonal Antibody*
The interaction of a mouse monoclonal antibody (4A6) and birch profilin, a structurally well conserved actin- and phosphoinositide-binding protein and cross-reactive allergen, was characterized. InExpand
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Monitoring CHO cell cultures: cell stress and early apoptosis assessment by mass spectrometry.
Mammalian cells, especially CHO (Chinese Hamster Ovary), are an important host for the production of biopharmaceuticals. Early detection of cellular stress and the onset of apoptosis, ultimatelyExpand
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Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations
Summary. Neurotransmitter release is modulated by presynaptic histamine H3 receptors located on histaminergic, noradrenergic and other nonhistaminergic neurons of the central and peripheral nervousExpand
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The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome.
The mouse WASP gene, the homolog of the gene mutated in Wiskott-Aldrich syndrome, has been isolated and sequenced. the predicted amino acid sequence is 86% identical to the human WASP sequence. AExpand
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High-level expression in Escherichia coli and purification of recombinant plant profilins: comparison of IgE-binding capacity and allergenic activity.
Because of their structural similarity and ubiquitous distribution as actin binding proteins, plant profilins represent important cross-reactive allergens for almost 20% of patients suffering fromExpand
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Human monoclonal IgG antibodies derived from a patient allergic to birch pollen as tools to study the in situ localization of the major birch pollen allergen, Bet v 1, by immunogold electron
BACKGROUND Bet v 1, the major birch pollen allergen, and related allergens present in various tree pollens, fruits, and vegetables represent a family of important cross-reactive allergens. AlthoughExpand
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Mutants and Variants of the Human Antidepressant-Sensitive Norepinephrine Transporter
The norepinephrine transporter (NET) is responsible for the rapid re-uptake of synaptically released NE. Substrate transport by neurotransmitter transporters (NTTs) is principially posible in bothExpand
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