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Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors
It is shown that the α4β3δ receptor has a distinct pharmacology and kinetic profile and with its restricted distribution within the brain and unique pharmacology this receptor may play an important role in the action of neurosteroids and anaesthetics.
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype
This work created genetically modified mice with a diazepam-insensitive α1 subtype and a selective BZ site ligand to explore GABAA receptor subtypes mediating specific physiological effects and revealed that the α1Subtype mediated the sedative, but not the anxiolytic effects of benzodiazepines.
DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling
The disrupted in schizophrenia 1 (DISC1) gene is disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness and a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP is proposed.
Which GABAA-receptor subtypes really occur in the brain?
Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor
Data suggest that α5-containing GABAA receptors play a key role in cognitive processes by controlling a component of synaptic transmission in the CA1 region of the hippocampus.
Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors.
It is shown that the alpha(4)beta(3)delta receptor has a distinct pharmacology and kinetic profile and may play an important role in the action of neurosteroids and anaesthetics.
Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.
- X. Peng, V. Gerzanich, R. Anand, P. Whiting, J. Lindstrom
- BiologyMolecular pharmacology
- 1 September 1994
Chronic nicotine exposure in tobacco smokers or experimental animals is shown to result in an increase in receptor amount, indicating that nicotine-induced up-regulation reflects properties of the alpha 4 beta 2 receptor protein, rather than being an adaptive response unique to the neurons in which these receptors are normally expressed.
Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells.
- T. Priestley, P. Laughton, J. Myers, B. Le Bourdellès, J. Kerby, P. Whiting
- Biology, ChemistryMolecular pharmacology
- 1 November 1995
These experiments demonstrate the usefulness of permanently transfected L(tk-) cells for electrophysiological studies of recombinantNMDA receptor function and provide the first detailed functional pharmacological analysis of human NMDA receptor subtypes.
Combined small molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors
The quick and high-efficiency derivation of nociceptors offers unprecedented access to this medically relevant cell type for studies of human pain, and use of small-molecule pathway inhibitors could become a general strategy for accelerating developmental timing in vitro.
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
It is shown that dysbindin and DISC1 share common PPIs suggesting they may affect common biological processes and that the function of schizophrenia risk genes may converge.