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Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors
The pharmacology of the stable cell line expressing human α4β3δ GABAA receptor was investigated using whole‐cell patch‐clamp techniques. α4β3δ receptors exhibited increased sensitivity to GABA whenExpand
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype
Inhibitory neurotransmission in the brain is largely mediated by GABAA receptors. Potentiation of GABA receptor activation through an allosteric benzodiazepine (BZ) site produces the sedative,Expand
DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling
The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene encodingExpand
Which GABAA-receptor subtypes really occur in the brain?
GABAA receptors are a heterogeneous family of ligand-gated ion channels responsible for mediating inhibitory neurotransmission in the CNS. Since the identification of mammalian cDNAs encoding 13Expand
Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor
The α5 subunit of the GABAA receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization and the function of α5-containing GABAAExpand
Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors.
1: The pharmacology of the stable cell line expressing human alpha(4)beta(3)delta GABA(A) receptor was investigated using whole-cell patch-clamp techniques. 2: alpha(4)beta(3)delta receptorsExpand
Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.
Chronic nicotine exposure in tobacco smokers or experimental animals is known to cause an increase in brain binding sites for nicotine. It has been proposed that this is an adaptive response ofExpand
Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells.
The pharmacological properties of two recombinant human N-methyl-D-aspartate (NMDA) receptor subtypes, comprising either NR1a/NR2A or NR1a/NR2B subunits permanently transfected into mouse L(tk-)Expand
Combined small molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors
Considerable progress has been made in identifying signaling pathways that direct the differentiation of human pluripotent stem cells (hPSCs) into specialized cell types, including neurons. However,Expand
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with cognitive deficits in both schizophrenics and the normal ageing population. In this study, we have generated aExpand