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Mild cognitive impairment
TLDR
A philosophical analysis of MCI is offered from epistemological, ethical and semantic perspectives and it is believed that the term should currently not be used clinically.
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Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.
TLDR
Demonstration of selective degeneration of neurons of the nucleus basalis of Meynert represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and points to a critical subcortical lesion in Alzheimer's patients.
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Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group
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Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
TLDR
The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex and loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinerential derangement in Alzheimer disease.
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Practice parameter: Diagnosis of dementia (an evidence-based review) Report of the Quality Standards Subcommittee of the American Academy of Neurology
TLDR
Dementia criteria for dementia have improved since the 1994 practice parameter, and further research is needed to improve clinical definitions of dementia and its subtypes, as well as to determine the utility of various instruments of neuroimaging, biomarkers, and genetic testing in increasing diagnostic accuracy.
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Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease
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Complex visual disturbances in Alzheimer's disease
TLDR
It is demonstrated that a range of complex visual disturbances are common in AD and suggests that they may result from the known neuropathology in the visual association cortex.
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Basal forebrain neurons in the dementia of Parkinson disease
TLDR
Investigation of 12 patients with Parkinson disease demonstrates that the demented patients with this disease also show a selective loss of cells in the nucleus basalis of Meynert, thus providing an important link between the dementias of Alzheimer disease and Parkinson disease.
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Disclosure of APOE genotype for risk of Alzheimer's disease.
TLDR
The disclosure of APOE genotyping results to adult children of patients with Alzheimer's disease did not result in significant short-term psychological risks and test-related distress was reduced among those who learned that they were APOE epsilon4-negative.
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Evaluation of dementia.
Dementia is the clinical syndrome characterized by acquired losses of cognitive and emotional abilities severe enough to interfere with daily functioning and the quality of life. The term does not…
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