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The Continuing Puzzle of the Great Oxidation Event
The rise of atmospheric O(2) was a milestone in the history of life. Although O(2) itself is not a climate-active gas, its appearance would have removed a methane greenhouse present on the earlyExpand
Hopanoids play a role in membrane integrity and pH homeostasis in Rhodopseudomonas palustris TIE-1.
Sedimentary hopanes are pentacyclic triterpenoids that serve as biomarker proxies for bacteria and certain bacterial metabolisms, such as oxygenic photosynthesis and aerobic methanotrophy. TheirExpand
Herpes Simplex Virus Type 1 DNA Is Immunostimulatory In Vitro and In Vivo
ABSTRACT Recently, prokaryotic DNAs containing unmethylated CpG motifs have been shown to be intrinsically immunostimulatory both in vitro and in vivo, tending to promote Th1-like responses. InExpand
Identification of the bacteriochlorophylls, carotenoids, quinones, lipids, and hopanoids of "Candidatus Chloracidobacterium thermophilum".
"Candidatus Chloracidobacterium thermophilum" is a recently discovered chlorophototroph from the bacterial phylum Acidobacteria, which synthesizes bacteriochlorophyll (BChl) c and chlorosomes likeExpand
Discovery, taxonomic distribution, and phenotypic characterization of a gene required for 3-methylhopanoid production
Hopanoids methylated at the C-3 position are a subset of bacterial triterpenoids that are readily preserved in modern and ancient sediments and in petroleum. The production of 3-methylhopanoids byExpand
Identification and quantification of polyfunctionalized hopanoids by high temperature gas chromatography-mass spectrometry.
Hopanoids are triterpenoids produced mainly by bacteria, are ubiquitous in the environment, and have many important applications as biological markers. A wide variety of related hopanoid structuresExpand
Identification of a methylase required for 2-methylhopanoid production and implications for the interpretation of sedimentary hopanes
The rise of atmospheric oxygen has driven environmental change and biological evolution throughout much of Earth’s history and was enabled by the evolution of oxygenic photosynthesis in theExpand
Sterol Synthesis in Diverse Bacteria
Sterols are essential components of eukaryotic cells whose biosynthesis and function has been studied extensively. Sterols are also recognized as the diagenetic precursors of steranes preserved inExpand
Fractionation of the methane isotopologues 13 CH 4 , 12 CH 3 D, and 13 CH 3 D during aerobic oxidation of methane by Methylococcus capsulatus (Bath)
Abstract Aerobic oxidation of methane plays a major role in reducing the amount of methane emitted to the atmosphere from freshwater and marine settings. We cultured an aerobic methanotroph,Expand
A Locus on Mouse Chromosome 6 That Determines Resistance to Herpes Simplex Virus Also Influences Reactivation, While an Unlinked Locus Augments Resistance of Female Mice
ABSTRACT During studies to determine a role for tumor necrosis factor (TNF) in herpes simplex virus type 1 (HSV-1) infection using TNF receptor null mutant mice, we discovered a genetic locus,Expand