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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
A Plastid of Probable Green Algal Origin in Apicomplexan Parasites
Observations indicate that the Apicomplexa acquired a plastid by secondary endosymbiosis, probably from a green alga.
Stepwise dismantling of adenovirus 2 during entry into cells
Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interaction.
The data suggest that a high affinity, potentially protein-protein interaction between parasite and organelle components is responsible for PVM-organelle association.
Increased internal and external bacterial load during Drosophila aging without life-span trade-off.
Designing conditions for in vitro formation of amyloid protofilaments and fibrils.
The results indicate that formation of amyloid occurs when the native fold of a protein is destabilized under conditions in which noncovalent interactions, and in particular hydrogen bonding, within the polypeptide chain remain favorable.
Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes
A new population of class II-enriched vesicles has been discovered in B lymphocytes that accumulate internalized antigen but are distinct from endosomes and lysosomes.
Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor
- Devin T. Wiley, P. Webster, A. Gale, Mark E. Davis
- Biology, ChemistryProceedings of the National Academy of Sciences
- 6 May 2013
It is reported that transferrin-containing gold nanoparticles can reach the brain parenchyma from systemic administration in mice through a receptor-mediated transcytosis pathway, aided by tuning the nanoparticles avidity to Tf receptor (TfR), which is correlated with nanoparticle size and total amount of Tf decorating the nanoparticle surface.
Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells
It is demonstrated that elevation in the intracellular free Ca2+ concentration of normal rat kidney (NRK) fibroblasts induces fusion of lysosomes with the plasma membrane, and this findings highlight a novel role for lysOSomes in cellular membrane traffic and suggest that fusion ofLysosome exocytosis may be an ubiquitous form of Ca2+.