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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented. Expand
A Plastid of Probable Green Algal Origin in Apicomplexan Parasites
Observations indicate that the Apicomplexa acquired a plastid by secondary endosymbiosis, probably from a green alga. Expand
Stepwise dismantling of adenovirus 2 during entry into cells
The results show that incoming adenovirus type 2 particles undergo a stepwise disassembly program necessary to allow progress of the virus in the entry pathway and release of the genome into the nucleus. Expand
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interaction.
The data suggest that a high affinity, potentially protein-protein interaction between parasite and organelle components is responsible for PVM-organelle association. Expand
Increased internal and external bacterial load during Drosophila aging without life-span trade-off.
It is concluded that Drosophila can tolerate a significant bacterial load and mount a large innate immune response without a detectable trade-off with life span; furthermore, microbes do not seem to limit life span under optimized laboratory conditions. Expand
Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor
- Devin T. Wiley, P. Webster, A. Gale, Mark E Davis
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 6 May 2013
It is reported that transferrin-containing gold nanoparticles can reach the brain parenchyma from systemic administration in mice through a receptor-mediated transcytosis pathway, aided by tuning the nanoparticles avidity to Tf receptor (TfR), which is correlated with nanoparticle size and total amount of Tf decorating the nanoparticle surface. Expand
Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes
A new population of class II-enriched vesicles has been discovered in B lymphocytes that accumulate internalized antigen but are distinct from endosomes and lysosomes. Expand
Designing conditions for in vitro formation of amyloid protofilaments and fibrils.
- F. Chiti, P. Webster, +4 authors C. Dobson
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 30 March 1999
The results indicate that formation of amyloid occurs when the native fold of a protein is destabilized under conditions in which noncovalent interactions, and in particular hydrogen bonding, within the polypeptide chain remain favorable. Expand
Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells
- Ana Rodríguez, P. Webster, J. Ortego, N. Andrews
- Biology, Medicine
- The Journal of cell biology
- 7 April 1997
It is demonstrated that elevation in the intracellular free Ca2+ concentration of normal rat kidney (NRK) fibroblasts induces fusion of lysosomes with the plasma membrane, and this findings highlight a novel role for lysOSomes in cellular membrane traffic and suggest that fusion ofLysosome exocytosis may be an ubiquitous form of Ca2+. Expand