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Intranasal delivery of morphine.
TLDR
It is concluded that a properly designed nasal morphine formulation (such as one with chitosan) can result in a non-injectable opioid product capable of offering patients rapid and efficient pain relief.
Nasal Delivery of Insulin Using Novel Chitosan Based Formulations: A Comparative Study in Two Animal Models Between Simple Chitosan Formulations and Chitosan Nanoparticles
TLDR
It was shown conclusively that chitosan nanoparticles did not improve the absorption enhancing effect of chitOSan in solution or powder form and that ch itosan powder was the most effective formulation for nasal delivery of insulin in the sheep model.
PecSys: in situ gelling system for optimised nasal drug delivery
TLDR
The lead product using PS is a fentanyl nasal spray formulation (NasalFent®), which has successfully met the primary objective in a pivotal Phase III clinical study and is scheduled for regulatory filings in the first half of 2009.
Drug-Delivery By Ion-Exchnage. Part VII: Release of Acidic Drugs from Anionic Exchange Resinate Complexes
AbstractThe loading and relase of ibuprofen, Ketoprofen and mefenamic acid from a range of strong anionic exchange resins, including cholestyramine, is decribed. Release rates into simulated gastric
Development of in vitro models to demonstrate the ability of PecSys®, an in situ nasal gelling technology, to reduce nasal run-off and drip
TLDR
In vivo, this enhancement of retention will provide optimum patient acceptability, modulate drug absorption and maximize the ability of drugs to be absorbed across the nasal mucosa and thus reduce variability in drug delivery.
Microencapsulation using emulsification/solvent evaporation: an overview of techniques and applications.
TLDR
This review describes the microencapsulation of pharmaceuticals using the technique of emulsification-solvent evaporation and speculates the clinical potential of microsphere-based drug delivery systems.
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