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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2-hydroxyglutarateExpand
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Robust Growth of Escherichia coli
The quantitative study of the cell growth has led to many fundamental insights in our understanding of a wide range of subjects, from the cell cycle to senescence. Of particular importance is theExpand
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NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling
The intracellular mechanism(s) by which a cell determines the duration of extracellular signal–regulated kinase (ERK) activation is not well understood. We have investigated the role of STEP, aExpand
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Structural insights into the YAP and TEAD complex.
The Yes-associated protein (YAP) transcriptional coactivator is a key regulator of organ size and a candidate human oncogene inhibited by the Hippo tumor suppressor pathway. The TEAD family ofExpand
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Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids.
G protein-coupled receptor 43 (GPR43) has been identified as a receptor for short-chain fatty acids that include acetate and propionate. A potential involvement of GPR43 in immune and inflammatoryExpand
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A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation.
Sox2 is a key factor for maintaining embryonic stem cell (ESS) pluripotency, but little is known about its posttranslational regulation. Here we present evidence that the precise level of Sox2Expand
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Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.
The target of rapamycin (TOR) complex 1 (TORC1) is a central cell growth regulator in response to a wide array of signals. The Rag GTPases play an essential role in relaying amino acid signals toExpand
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Subcellular Localization of β-Arrestins Is Determined by Their Intact N Domain and the Nuclear Export Signal at the C Terminus*
β-Arrestin1 and β-arrestin2 play a key role in the regulation of G protein-coupled receptor-mediated signaling, whereas the subcellular distribution of β-arrestin1 and β-arrestin2 has been shown toExpand
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Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD
  • Jingdong Cheng, Yi Yang, +7 authors Y. Xu
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 16 November 2012
Background: UHRF1 is an important epigenetic regulator connecting DNA methylation and histone methylations. Results: PHD-H3 interaction is independent of the TTD, whereas TTD-H3K9me3 interaction theExpand
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Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating
BACKGROUND & AIMS Nearly 20% of the global cancer burden can be linked to infectious agents. Fusobacterium nucleatum promotes tumor formation by epithelial cells via unclear mechanisms. We aimed toExpand
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