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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
2-HG is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases, leading to genome-wide histone and DNA methylation alterations.
Robust Growth of Escherichia coli
The long-term growth and division patterns of Escherichia coli cells are studied by employing a microfluidic device designed to follow steady-state growth anddivision of a large number of cells at a defined reproductive age to conclude that E. coli has a robust mechanism of growth that is decoupled from cell death.
Structural insights into the YAP and TEAD complex.
The three-dimensional structure of the YAP-TEAD1 complex is reported, in which YAP wraps around the globular structure of TEAD1 and forms extensive interactions via three highly conserved interfaces.
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling
It is shown that activation of NMDA receptors led to activation of STEP, which limited the duration of ERK activity as well as its translocation to the nucleus and its subsequent downstream nuclear signaling.
Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids.
In a mouse in vivo model, the activation of GPR43 by acetate results in the reduction in plasma free fatty acid levels without inducing the flushing side effect that has been observed by theactivation of nicotinic acid receptor, GPR109A.
Subcellular Localization of β-Arrestins Is Determined by Their Intact N Domain and the Nuclear Export Signal at the C Terminus*
- P. Wang, Yalan Wu, X. Ge, Lan Ma, G. Pei
- Biology, MedicineThe Journal of Biological Chemistry
- 28 March 2003
It is suggested that both the nuclear export signal motif and the N domain of β-arrestins are critical for the regulation of their subcellular localization and that β-Arrestin2 may modulate the function of its binding partners such as Mdm2 and JNK3 by alteration of theirSubcellular distribution.
Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.
The crystal structure of the Gtr1p-Gtr2p complex, the Rag homologs from Saccharomyces cerevisiae, is presented, revealing a pseudo-twofold symmetric organization of the heterodimeric GTPases.
Biocalalyst effects of immobilized anthraquinone on the anaerobic reduction of azo dyes by the salt-tolerant bacteria.
The experiments explored a great improvement of the redox mediator application and the new bio-treatment concept and the effects of various operating conditions such as anthraquinone bead number, dissolved oxygen, temperature and pH on microbial decolorization were investigated experimentally.
A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation.
Evidence is presented that the precise level of Sox2 proteins in ESCs is regulated by a balanced methylation and phosphorylation switch, and in mouse ESCs, AKT1 activity toward Sox2 is greater than that of Set7, leading to Sox2 stabilization and ESC maintenance.
Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating…
Fusobacterium nucleatum increased proliferation and invasive activities of CRC cell lines compared with control cells and levels of F nucleatum DNA and miR21 were increased in tumor tissues compared with non-tumor colon tissues from patients.