• Publications
  • Influence
Nitric oxide donors: chemical activities and biological applications.
O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth
TLDR
It is shown that glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the PPP, is dynamically modified with an O-linked β-N-acetylglucosamine sugar in response to hypoxia, revealing a mechanistic understanding of how O-glycosylation directly regulates the P PP to confer a selective growth advantage to tumours. Expand
Combined Biosynthetic Pathway For De Novo Production of UDP‐Galactose: Catalysis with Multiple Enzymes Immobilized on Agarose Beads
TLDR
The results show that de novo production of UDP‐galactose on the super‐bead column is more efficient than in solution because of the stability of the immobilized enzymes. Expand
Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion.
TLDR
The results indicate that glycosidic linkage of sialic acid is a potential target for superoxide and other related ROS. Expand
Nonlabeled quartz crystal microbalance biosensor for bacterial detection using carbohydrate and lectin recognitions.
TLDR
It is demonstrated here for the first time that a carbohydrate nonlabeled mass sensor in combination with lectin-bacterial O-antigen recognition can be used for detection of high molecular weight bacterial targets with remarkably high sensitivity and enhanced specificity. Expand
Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide.
  • W. Yi, J. Shao, +11 authors P. Wang
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 23 February 2005
TLDR
This study sequenced the entire E. coli O86 antigen gene cluster and identified all the genes responsible for O-antigen biosynthesis by sequence comparative analysis, and identified a new bacterial glycosyltransferase equivalent to human blood group transferase B. Expand
Extreme Substrate Promiscuity of the Neisseria Oligosaccharyl Transferase Involved in Protein O-Glycosylation*
TLDR
It is demonstrated that PglL is able to transfer virtually any glycan from the undecaprenyl pyrophosphate (UndPP) carrier to pilin in engineered Escherichia coli and Salmonella cells, and it is proposed that the primary roles of the lipid carrier during O-glycosylation are the translocation of the glycan into the periplasm, and the positioning of the pyroph phosphate linker and glycan adjacent to Pgl L. Expand
Current understanding on biosynthesis of microbial polysaccharides.
TLDR
Based on the assembly and translocation mechanisms, O-antigen biosynthesis is subdivided into three pathways, of which the Wzy-dependent pathway is widely used not only in O-anigen, but also in CPS and EPS. Expand
Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy.
TLDR
N nanoparticle formulated alpha-galactosylceramide is an attractive immunomodulator for immunotherapy and vaccine development and future studies will be focused on its application as adjuvant for protein and/or peptide antigens. Expand
Immunologic glycosphingolipidomics and NKT cell development in mouse thymus.
TLDR
A glycosphingolipidomics study of mouse thymus, and studied mice mutants which are deficient in beta-hexosaminidase b or alpha-galactosidase A, two glycosidases that are up- and downstream agents of iGb3 turnover, generated a first database for glycospindingolipids expressed in mouse thylacine, which are specifically regulated by rate-limiting glycosidyases. Expand
...
1
2
3
4
5
...