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Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis
A systemic inflammatory response is observed in patients undergoing hemorrhagic shock and sepsis. Here we report increased levels of cold-inducible RNA-binding protein (CIRP) in the blood ofExpand
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Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation
Although the cloning and molecular characterization of MFG-E8 was first reported in the early 90s, breakthrough on MFG-E8 research came into light when it was explored as an outstanding factor forExpand
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Antiangiogenic Properties of Gold Nanoparticles
Here, we report an intrinsic property of gold nanoparticles (nanogold): they can interact selectively with heparin-binding glycoproteins and inhibit their activity. Gold nanoparticles specificallyExpand
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β-Arrestin-dependent Regulation of the Cofilin Pathway Downstream of Protease-activated Receptor-2*
β-Arrestins are pleiotropic molecules that mediate signal desensitization, G-protein-independent signaling, scaffolding of signaling molecules, and chemotaxis. Protease-activated receptor-2 (PAR-2),Expand
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Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-γ Activation
Curcumin, the phytochemical component in turmeric, is used as a dietary spice and a topical ointment for the treatment of inflammation in India for centuries. Curcumin (diferuloylmethane) isExpand
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Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease
Maintaining tolerance of T cells to self-antigens is essential to avoid autoimmune disease. How self-reactive T cells are kept functionally inactive is, however, unknown. In this study, we show thatExpand
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Spermine Protects Mice Against Lethal Sepsis Partly by Attenuating Surrogate Inflammatory Markers
The pathogenesis of sepsis is partly attributable to dysregulated inflammatory response mediated by pathogen-associated molecular patterns (PAMPs) (for example, endotoxin) and damage-associatedExpand
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A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester.
Apoptotic cell phagocytosis has recently raised considerable interest, particularly due to its intricate molecular mechanisms and negative immunologic impact of incompetent clearance of apoptoticExpand
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Ghrelin Down-regulates Proinflammatory Cytokines in Sepsis Through Activation of the Vagus Nerve
Objective:To test the hypothesis that administration of ghrelin attenuates inflammatory responses in sepsis through vagal nerve stimulation. Summary Background Data:Ghrelin has been demonstrated toExpand
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