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Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery
Background Breast cancer cell lines have been used widely to investigate breast cancer pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it is important to… Expand
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.
- Y. Sun, P. Wang, H. Zheng, R. Smith
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 30 March 2004
Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pattern of GH-release in the elderly, and increase lean but not fat mass in obese subjects. Screening of… Expand
Extensive and coordinated transcription of noncoding RNAs within cell cycle promoters
Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to external stimuli, but the scope and functions of such activity are not known.… Expand
Cyclin A1 is required for meiosis in the male mouse
- D. Liu, M. Matzuk, W. K. Sung, Q. Guo, P. Wang, D. Wolgemuth
- Biology, Medicine
- Nature Genetics
- 1 December 1998
The mammalian A-type cyclin family consists of two members, cyclin A1 (encoded by Ccna1) and cyclin A2 (encoded by Ccna2). Cyclin A2 promotes both G1/S and G2/M transitions, and targeted deletion of… Expand
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms.
We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms (SNPs). This map is based on a comparison of the sequences of three domestic chicken… Expand
Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2
Biochemical and genetic studies place the amyloid precursor protein (APP) at the center stage of Alzheimer's disease (AD) pathogenesis. Although mutations in the APP gene lead to dominant inheritance… Expand
linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer.
OBJECTIVES The human genome encodes many long intergenic noncoding RNAs (lincRNAs). However, their biological functions, molecular mechanisms and prognostic values associated with bladder cancer… Expand
Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.
- D. Tabb, Lorenzo J Vega-Montoto, +29 authors C. Spiegelman
- Chemistry, Medicine
- Journal of proteome research
- 5 February 2010
The complexity of proteomic instrumentation for LC-MS/MS introduces many possible sources of variability. Data-dependent sampling of peptides constitutes a stochastic element at the heart of… Expand
Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of β-Amyloid Precursor Protein*
- D. Cai, J. Y. Leem, +10 authors H. Xu
- Medicine, Biology
- The Journal of Biological Chemistry
- 31 January 2003
Presenilins (PS1/PS2) play a critical role in proteolysis of β-amyloid precursor protein (βAPP) to generate β-amyloid, a peptide important in the pathogenesis of Alzheimer's disease. Nevertheless,… Expand
LncRNA SNHG12 contributes to multidrug resistance through activating the MAPK/Slug pathway by sponging miR-181a in non-small cell lung cancer
Small nucleolar RNA host gene 12 (SNHG12), as one of the long non-coding RNAs (lncRNAs), plays an oncogenic role in various cancers, however, its role in the chemoresistance of non-small cell lung… Expand